Metformin Teva

/ Teva

Take the medicine with or immediately after a meal, with a cup of water.
Do not change the dosage, dosing times or the diet associated with treatment on your own.
Adults: The usual initiation dose is 500 mg or 850 mg (one tablet) 3-2 times a day. The maximum daily dose was 2550 mg per day, divided into 3 doses.
Patients with renal failure  – lower dosage may be necessary. Patients  under insulin treatment, should be well instructed about the initiation of treatment of metformin.
Children  over 10 years old: initial dose 500 or 850 mg once daily, maximal daily dose is 2000mg in two, three divided doses.
Renal impairment: lower dose may be used in patients with renal impairment.
Patients under insulin therapy : the dosage of metformin has to adjusted individually.

Treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control.
•In adults, metformin may be used as monotherapy or in combination with other oral anti-diabetic agents or with insulin.•In children from 10 years of age and adolescents, metfomin may be used as monotherapy or in combination with insulin.
A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure

Known hypersensitivity to the drug, or to any other ingredients of the preparation. Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels above or equal to 15 mg/liter for the adults of abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse (shock), acute disease such as dehydration (diarrhea, vomiting, fever), severe infectious and/or hypoxic states (septicemia, urinary infection, pneumopathy). Hypoxic states: cardiovascular collapse (shock) from whatever cause, acute congestive heart failure, acute myocardial infarction and other conditions characterized by hypoxemia (any severe respiratory disturbances). Hepatic failure, since severe hepatic dysfunction has been associated with some cases of lactic acidosis. Should generally be avoided in patients with clinical or laboratory evidence of hepatic disease. Should be temporarily withheld in patients undergoing radiologic studies involving parenteral administration of iodinated contrast materials except for fluorescein photoretinography which does not necessitate metformin withhold, because use of such products may result in acute alteration of renal function. See prescribing information. Excessive alcohol intake, acute or chronic. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin. During and for 2 days following surgery or any traumatic condition. History of lactic acidosis. Pregnancy and lactation.