Klacid Tablets

/ Abbott

Adults: The usual recommended dosage of Klacid SR Tablets in adults is one
500mg modified-release tablet daily to be taken with food . In more severe
infections, the dosage can be increased to two 500mg modified-release tablets
daily. The usual duration of treatment is 6 to 14 days.
Children older than 12 years: As for adults.
Children younger than 12 years: Use of Klacid SR are not recommended for
children younger than 12 years. Clinical trials have been conducted using
clarithromycin peadiatric suspension in children 6 months to 12 years of age.
Therefore, children under 12 years of age should use clarithromycin peadiatric
suspension (granules for oral suspension).
Renal impairment: In patients with renal impairment with creatinine clearance less than 30 mL/min, the dosage of clarithromycin should be reduced by one-half, i.e. 250 mg once daily, or 250 mg twice daily in more severe infections. Treatment should not be continued beyond 14 days in these patients. Because the tablet cannot be split, the dose cannot be reduced from 500 mg daily, Klacid SR Tablets should not be used in this patient population.

Upper and lower respiratory tract infections, skin and soft tissue infections, MCA in AIDS. Combined treatment with other drugs for duodenal ulcer with helicobacter pylori, otitis media.

Hypersensitivity to clarithromycin, erythromycin or any of the macrolide antibiotics.
See prescribing information for full details.

Pregnancy, lactation, renal or hepatic impairment. In concomitant use with theophylline, carbamazepine or digoxin (for the heart), monitoring of serum concentrations should be performed.

Requiring special attention: Acute or continuous diarrhea, strong abdominal pain, yellowing of the skin or eyes, allergic reaction, rash, irritation or itching of skin, anaphylaxis reaction. Mild effects may persist: Nausea/vomiting, mild abdominal pain, indigestion, headache, skin rash and change in taste.

Theophylline, warfarin, digoxin, carbamazepine, terfenadine, astemizole, zidovudine, ergot derivatives.