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  • Duac
    / Perrigo


    Active Ingredient *

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Gel

    25 gr

    not in the basket chart 23399 4544

    Related information


    Dosage

    Adults and Adolescents (aged 12 years and above): Duac gel should be applied once daily in the evening, to the entire affected area.
    Patients should be advised that excessive application will not improve efficacy, but may increase the risk of skin irritation. If excessive dryness or  peeling occurs, frequency of application should be reduced or application temporarily interrupted.
    An effect on inflammatory and non-inflammatory lesions may be seen as early as week 2-5 of treatment.
    The safety and efficacy of Duac Gel has not been studied beyond 12 weeks in acne vulgaris clinical trials.
    Treatment with Duac Gel should not exceed more than 12 weeks of continuous use.
    Pediatric population: The safety and efficacy of Duac gel has not been established in children under 12 years of age, therefore Duac gel is not recommended for use in this population.
    Elderly patients: No specific recommendations.
    Method of administration: Duac Gel should be applied in a thin film after washing gently with a mild cleanser and fully drying. If the gel does not rub into the skin easily, too much is being applied.
    Hands should be washed after application.


    Indications

    Mild to moderate acne vulgaris, particularly inflammatory lesions.


    Contra-Indications

    Known hypersensitivity to clindamycin, lincomycin, benzoyl peroxide or any of the excipients in the formulation.


    Special Precautions

    Contact with the mouth, eyes and mucous membranes and with abraded or eczematous skin should be avoided. Application to sensitive areas of skin should be made with caution. In the event of accidental contact with the eyes, bathe with copious amounts of water. Should be used with caution in patients with a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis. It should also be used with caution in atopic patients, in whom further skin drying may occur. The frequency of application should be reduced if excessive irritation or dryness develops. If prolonged or significant diarrhea occurs or the patient suffers from abdominal cramps, treatment with should be discontinued immediately, as the symptoms may indicate antibiotic-associated colitis. The product may bleach hair or coloured fabrics. It is recommended that exposure to sun or sunlamps should be minimized. Patients should be advised that, in some cases, 4-6 weeks of treatment may be required before the full therapeutic effect is observed. Cross-resistance may occur with other antibiotics such as lincomycin and erythromycin when using antibiotic monotherapy. Local recommendations about antibiotic use and prevalence of acquired resistance should be taken into consideration.


    Side Effects

    Very common: Skin and subcutaneous tissue disorders, erythema, peeling, dryness.
    Common: Skin and subcutaneous tissue disorders, burning, pruritus.


    Drug interactions

    Concomitant topical antibiotics, medicdbated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol and/or astringents, should be used with caution as a cumulative irritant effect may occur. Simultaneous application with topical acne preparations containing vitamin A derivatives should be avoided. Potential synergism exists between clindamycin and gentamycin.


    Pregnancy and Lactation

    Pregnancy: Should only be prescribed to pregnant women after careful risk/benefit assessment. Should be used with caution when adequate contraception is not being practised.
    Lactation: Treatment of nursing mothers is not recommended.


    Manufacturer
    Glaxo Operations UK Ltd
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