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  • Bonserin
    / Rafa

    Active Ingredient

    Status in Israel

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft


    20 X 30 mg

    partial basket chart 8273 2364

    Related information


    The daily dose can be taken either in divided doses or as a single dose at night (due to the favourable effect on sleep).
    It is often advantageous to maintain antidepressant treatment for several months after clinical improvement has occurred. In order to ensure an optimal antidepressant effect the dosage of mianserin should not be reduced.
    Adults: Treatment should usually commence with 30 mg mianserin per day increasing gradually as necessary. The effective dosage usually lies between 30 mg and 90 mg. Divided doses of up to 200 mg are well tolerated.
    Older people: The use of mianserin is restricted to patients over 65 who:
    – do not respond to other antidepressant drugs
    – have glaucoma
    – have prostatic hypertrophy
    Not more than 30 mg a day initially. Any increase in dose should be under close medical supervision. A lower than normal maintenance dose may be sufficient to produce a satisfactory clinical response.
    Pharmacokinetic studies of mianserin in the elderly patient suggest a longer half-life and slower metabolic clearance. This information implies that a single night time dose of mianserin should be preferable to the divided dose in older people; in addition a lower than normal maintenance dose may be sufficient to produce a satisfactory clinical response.
    Paediatric population: Mianserin should not be used in the treatment of children and adolescents under the age of 18 years.
    Method of administration: For oral use. The tablets should be swallowed without chewing. If the tablet is halved in order to make the swallowing easier, both half tablets must be taken.


    For the treatment of depression.


    Hypersensitivity to the active substance or to any of the excipients. Mania.
    Severe liver disease.

    Rafa Laboratories Ltd.