All the Drug Class Drugs
Iron Chelating Agent. Deferasirox 125, 250, 500 mg. DISPERS. TABS: 28. See lit.
Tmt. of chronic iron overload due to blood
transfuse. in adult & pediat. pts. (2 yrs and
over). Tmt. of chronic iron overload in pts.
with non-transfus.-depend. thalassemia
syndr. aged 10 yrs and older. Chelation ther.
should only be init. when there is evidence of iron overload (liver iron concentration [LIC] 5 mg Fe/g [dw] or serum ferritin consist. >800 g/l). LIC is the pref. method of iron overload determin. and should be used wherever available.
C/I: Hypersens. to the product. High risk
myelodysplastic syndrome pts. and pts.
with other hematology. and nonhematolog.
malign. who are not
expected to benefit from chelation ther.
due to the rapid progress. of their
disease. CLcr < 60 mL/min or serum cr >2
times the age-appropr. ULN. PLT counts
<50 x 109/L.