All the Drug Class Drugs
Immunostimulant. Mifamurtide 4 mg/vial. VIAL (pwdr. for concentrate. for dispers. for infus.): 1×4 mg. After reconstit. to final volum. of 50 ml, each ml of suspens. contains 0.08 mg mifamurtide.
Pts. 2-30 yrs.: 2 mg/m2 bdy. surf. As adjuvant ther. follow. resect.: twice wkly. at least 3 d apart for 12 wks., follow. by once wkly. tmts. for an addit. 24 wks. for a total of 48 infus in 36 wks. For special populat. See lit.
Tmt. in child., adolesc. & young adult. with. high grade, resectab., nonmetastat. osteosarcoma aft. macroscopic. Complete surg. resect. In combinat. with post-op. multi-agent chemother. Safety and effic. assessed in pts. 2-30 yrs at init. diagn.
C/I: Hypersens., Concurr. use with cyclosporine/other calcineurin inhibit., high-dose NSAIDs, cyclooxygenase inhibit.
Immunostimulant. Plerixafor 24 mg / 1.2 ml. VIAL: 1. 0.24 mg/kg bdy weight/ dly,
admin S.C. inject. 6-11 hrs prior to
initiat. of apheresis follow. 4 day pretmt.
with granulocyte-colony stimulat.
factor (G-CSF).
In combinat. with G-CSF to enhance
mobilisat. hematopiet. stem cells to
periph. blood for collect. and subseq.
autologous transplant. in pts. with
lymphoma and multiple myeloma.
C/I: Hypersens.
Immunostimulant. Bacillus Calmette-Guérin (BCG) 2-8X10^8 CFU. VIAL Pwder. for sol. for instill. into the bladder.1/3 X 2-8 x 108 CFU
Weekly instill. during the first 6 weeks. Maint. weekly during 3 consecutive weeks at months 3, 6, and 12 after initiation. Assess after 1 year from initiation.
For flat urothelial cell carcinoma in situ (CIS) of the bladder and as an adj. ther. after transurethral resection (TUR) of a primary or relapsing superf. papillary urothelial cell carcinoma of the bladder stage Ta (grade 2 or 3) or T1 (grade 1 2 or 3).
This drug is only recommended for stage Ta grade 1 papillary tumors when there is a high risk of tumor recurrence.
C/I: Hypersens. UTI. Ther. should be interrupted until the bacterial culture from urine becomes neg. and ther. with antibiotics and/or urinary antiseptics is stopped. Gross haematuria. In these cases, ther. should be stopped or postponed until the haematuria has been successfully treated or has resolved. In pts with a pos.Tuberculin test, instillations are contra-indic. only if there is supplementary medical evidence for an active TB infect. Tmt. with anti-TB drugs like streptomycin, para-amino-salicylic acid (PAS), isoniazid (INH), rifampicin and ethambutol. Impaired immune resp. irrespective of whether this impairment is congenital or caused by dis., drugs or other ther. Positive HIV serology. Pregn. and lactation.
