All the Active Ingredient Drugs
Immunostimulant. Bacillus Calmette-Guérin (BCG) 2-8X10^8 CFU. VIAL Pwder. for sol. for instill. into the bladder.1/3 X 2-8 x 108 CFU
Weekly instill. during the first 6 weeks. Maint. weekly during 3 consecutive weeks at months 3, 6, and 12 after initiation. Assess after 1 year from initiation.
For flat urothelial cell carcinoma in situ (CIS) of the bladder and as an adj. ther. after transurethral resection (TUR) of a primary or relapsing superf. papillary urothelial cell carcinoma of the bladder stage Ta (grade 2 or 3) or T1 (grade 1 2 or 3).
This drug is only recommended for stage Ta grade 1 papillary tumors when there is a high risk of tumor recurrence.
C/I: Hypersens. UTI. Ther. should be interrupted until the bacterial culture from urine becomes neg. and ther. with antibiotics and/or urinary antiseptics is stopped. Gross haematuria. In these cases, ther. should be stopped or postponed until the haematuria has been successfully treated or has resolved. In pts with a pos.Tuberculin test, instillations are contra-indic. only if there is supplementary medical evidence for an active TB infect. Tmt. with anti-TB drugs like streptomycin, para-amino-salicylic acid (PAS), isoniazid (INH), rifampicin and ethambutol. Impaired immune resp. irrespective of whether this impairment is congenital or caused by dis., drugs or other ther. Positive HIV serology. Pregn. and lactation.
