All the Drug Class Drugs
Direct-acting Antiviral. Remdesivir 100 mg. VIAL (pwdr. for concentrate for sol. for infus.):1×100 mg. 1st Day: 200 mg. Day 2nd -5th : 100 mg.
Tmt. of COVID-19 in adult. & in adolesc. (aged 12 -18 yrs. wt. ≥ 40 kg) with pneum. requir. supplemental oxygen (low- or high-flow oxygen or other non-invas. ventilation at start of tmt.)
C/I: Hypersens.
Direct-acting Antiviral. Sofosbuvir 400 mg, Velpatasvir 100 mg. F.C. TABS.: 28. 1 tab×1/d. with food. Recommen. tmt. durations for all HCV genotypes (DAA: direct-act. antivir. agent): DAA naïve pts. without cirrhosis: 8 wks. DAA naïve pts. with compensat. cirrhosis: 12 wks., 8 wks. may be consid. in genotype 3 infect. pts. DAA experience. pts. without cirrhosis/ with compensat. cirrhosis: 12 wks. See lit.
Tmt. of chronic HCV infec. in adults.
C/I: Hypersens. Concom. use with strong P-glycoprotein (P-gp) and/or strong cytochrome P450 (CYP) induc. (e.g. rifampicin, rifabutin, St. John’s wort [Hypericum perforatum], carbamazepine, phenobarbital and phenytoin).
Concom. use with rosuvastatin or dabigatran etexilate.
Concom. use with ethinylestradiol-contain. agent. e.g. comb. oral contracept. or contracept. vag. rings.
