3rd Generation Cephalosporins

7 Drugs classified under this drug class

3rd Generation Cephalosporins. Ceftazidime as pentahydrate 1 g/vial.
VIAL (Pwdr. for sol. for IV/IM inj.): 10. Dosage must be ajust. individ. accord. to the type of infec. and age of the pt.
Tmt. of the infec. listed below in adult.&child. include. neonates (from birth).
Nosocomial pneum. Broncho-pulmon. infec. in CF. Bact. mening. Chron. suppurative otitis m. Malign. otitis externa. Complic. UTI. Complic. skin & soft tissue infec. Complic. intra-abdom. infec. Bone & joint infec.Peritonitis assoc. with dialysis in pt. on CAPD. Tmt. of pts. with bacteraemia that occurs in association with, or is suspect. to be associated with, any of the infec. listed above.
May be used in the manag. of neutropenic pts. with fever that is suspect. to be due to a bact. infect.
Ceftazidime may be used in the peri-operat. prophylaxis of UTI  for pts. underg.  trans-urethral resect. of the prostate (TURP).
The selection of ceftazidime should take into account its antibact. spectrum, which is mainly restrict. to aerobic Gram neg. bact.
Ceftazidime should be co-admin. with other antibact. agents whenever the possible range of causive bacteria would not fall within its spect. of activity.
Consid. should be given to official guidelines on the appropr. use of antibact. agents.
C/I: Hypersens. to ceftazidime, or to any other cephalosp. antibiot.
History of severe hypersens.(e.g. anaphylac. react. to any other type of beta-lactam antibact. agent (penicillins, monobactams, carbapenems).

3rd Generation Cephalosporins. Ceftriaxone 1 g.
VIAL (Pwdr. for sol. for inf/inj) 1/5/10/55 × 1 g. Dose depends on the severity, suscept., site and type of infect.  and on the age and hepato-renal funct.  of the pt. See lit.
Tmt. of the follow. infec. in adult. & child. includ. term neonates (from birth):
-Bact. Meningitis/ Commun.  acquir.  pneumon. /Hospital acquir.  pneumon./Acute otitis media/Intra-abdom. infect./Complicat. UTI (includ. pyelonephritis)/Infect.  of bones &  joints/Complic. skin & soft tissue infect./ Gonorrhoea-Syphilis/Bact. endocarditis.
May be used for:
Acute exacerbat. of COPD in adults/ Tmt. of disseminaed Lyme borreliosis (early (stage II) & late  (stage III) in adults & child.  includ.  neonates from 15 days of age/
Pre-operat. prophylax.  of surg. site infect./
In the manag. of neutropenic pts. with fever that is suspect. to be due to a ceftriaxone – suscept. bact.  infect./Ttmt.  of pts.  with bacteremia that occurs in associat.  with, or is suspect. to be assoc.  with, any of the infect. listed above. Ceftriaxone should be co-admin.  with other antibact. agents whenever the possible range of causative bacteria would not fall within its spectrum.
C/I: Hypersens.
History of severe hypersens.  (e.g. anaphyl.  react. ) to any other type of beta-lactam antibact.  agent (penicillins, monobactams, carbapenems).
Premature neonates up to a postmenstrual age of 41 wks. (gestat. age
+ chronological age).
Full-term neonates (up to 28 d of age): - with hyperbilirubinaemia, jaundice, or who are hypoalbuminaemic or acidotic because these are condit. in which bilirubin bind.  is likely to be impaired , if they require (or are expected to require) IV calcium tmt., or calcium-contain. infus. due to the risk of precip. of a ceftriaxone-calcium salt .
Contraindic. to lidocaine must be excluded before IM inj. of ceftriaxone when lidocaine sol. is used as a solvent. Ceftriaxone sol. contain. lidocaine should never be admin. IV. See lit.

3rd Generation Cephalosporins. Ceftriaxone as Disodium Hemiheptahydrate 1 g.
VIAL (Pwdr. for sol. for IM/IV inj.): 10×10 ml. The dose depends on the severity, suscept., site and type of infec. and on the age and hepato-renal funct. of the pt. See lit.
Tmt. of the follow. infec. in adult. & child. include. term neonates (from birth):-Bact. Meningitis. -Commun. acquir. pneumon.
-Hospital acquir. pneumon. -Acute otitis media. -Intra-abdom. infec. -Complicat. UTI (includ. pyelonephritis). -Infec. of bones &  joints. -Complic. skin & soft tissue infec.
-Gonorrhoea. -Syphilis. - Bact. endocarditis.
For tmt. of  acute exacerbat. of COPD in adult.
For tmt. of disseminat. Lyme borreliosis (early (stage II) & late (stage III) in adult. & child. include. neonates from 15 days of age.
For pre-operat. prophylax. of surg. site infec.
In the manag. of neutropenic pts. with fever that is suspect. to be due to a ceftriaxone – suscept. bact. infec.
In the tmt. of pts. with bacteremia that occurs in associate. with, oris suspect. to be assoc. with, any of the infecs. listed above Ceftriaxone should be co-admin. with other antibact. agents whenever the possible range of causative bacteria would not fall within its spectrum.
C/I: Hypersens. History of severe hypersens. (e.g. anaphyl. react. ) to any other type of beta-lactam antibact. agent (penicillins, monobactams, carbapenems).
Premature neonates up to a postmenstrual age of 41 wks. (gestat. age+chronological age). Full-term neonates (up to 28 d of age): - with hyperbilirubinaemia, jaundice, or who are hypoalbuminaemic or acidotic because these are condit. in which bilirubin bind. is likely to be impair., if they require (or are expected to require) IV calcium tmt., or calcium-contain. infus. due to the risk of precip. of a ceftriaxone-calcium salt.
Contraindic. to lidocaine must be excluded before IM inj. of ceftriaxone when lidocaine sol. is used as a solvent.
Ceftriaxone sol. contain. lidocaine should never be admin. IV. See lit.

3rd Generation Cephalosporins. Ceftazidime (as pentahydrate) 1 g/vial, 2 g/vial.
VIALS: 1 g, 2 g. 1-6 g dly. See lit. Child
and inf: 30-100 mg/kg/dly. See lit.
Tmt. of the infec. listed below in adults
and child. includ. neonates (from birth).
Nosocomial pneum.,Broncho-pulmon.
infect.in CF. Bact. mening. Chron.
suppurate. otitis med. Malign. otitis exter.
Complic.UTI. Complic. skin and soft tissue
infec. Complic. intra-abdom.infec. Bone
and joint infec. Peritonitis assoc.with
dialysis in pt. on CAPD. Tmt. of pts. with
bacteraemia that occurs in assoc. with, or
is suspected to be assoc. with, any of the
infec. listed. Manag. of neutropenic pts.
with fever that is suspected to be due to a
bacterial infec. Peri-operati. prophylaxis
of urin.tract. infec. for pts. undergoing
TURP.
C/I: Hypersens., history of severe
hypersens.(e.g. anaphylac. reac.) to any
other type of beta-lactam antibact.
agent (penicillins, monobactams,
carbapenems).

3rd Generation Cephalosporins. Ceftriaxone (as Sodium) 1 g/vial.
VIALS: 10. 1 g-2 g/day I.M., I.V. or infus.
See lit.
Infects. caused by pathogens sens. to
ceftriaxone such as sepsis meningit.,
respir., GI, genito-urin., bone and soft
tissue, wounds, gonorrh.
C/I: Hypersens., pregn.

3rd Generation Cephalosporins. Ceftazidime (as Pentahydrate) 1 g, 2 g.
VIAL: 1 x 1 g, 2 g. Parenteral I.V./I.M. into
large muscl. mass. Adults: 1-6 g dly
every 8 or 12 hrs. Most infects: 1 g 8
hrly or 2 g 12 hrly. Urin. tract and less
severe infects: 500 mg or 1 g 12 hrly.
Immunocompromised pts., neutropen:
2 g 8 hrly or 3 g 12 hrly. Proph. in
prostat. surg: 1 g at anesthes. Possible
2nd dose on removal of catheter.
Elderly: Max. dly dose: 3 g. Cystic
fibrosis: Adults with pseudonom. lung
infects: 100-150 mg/kg/day in 3 div.
doses. See lit. Inf. and child: Over 2
mths: 30-100 mg/kg/day in 2-3 div.
doses. Up to 150 mg/kg/day (max: 6 g/
day) in 3 div. doses to infect.
immunocompromised/fibrocyt. child,
child with meningit. Neonates and child up to 2 mths: 25-60 mg/kg/day in
2 div. doses proven effect. Impaired
ren. funct: Reduce dose. See lit. Ren.
impair: See lit.
Bact. infects. due to suscept. microorgans.
C/I: Hypersens.