All the Active Ingredient Drugs
3rd Generation Cephalosporins. Ceftriaxone as Disodium Hemiheptahydrate 1 g. VIAL (Pwdr. for sol. for IM/IV inj.): 10×10 ml. The dose depends on the severity, suscept., site and type of infec. and on the age and hepato-renal funct. of the pt. See lit.
Tmt. of the follow. infec. in adult. & child. include. term neonates (from birth):-Bact. Meningitis. -Commun. acquir. pneumon.
-Hospital acquir. pneumon. -Acute otitis media. -Intra-abdom. infec. -Complicat. UTI (includ. pyelonephritis). -Infec. of bones & joints. -Complic. skin & soft tissue infec.
-Gonorrhoea. -Syphilis. - Bact. endocarditis.
For tmt. of acute exacerbat. of COPD in adult.
For tmt. of disseminat. Lyme borreliosis (early (stage II) & late (stage III) in adult. & child. include. neonates from 15 days of age.
For pre-operat. prophylax. of surg. site infec.
In the manag. of neutropenic pts. with fever that is suspect. to be due to a ceftriaxone – suscept. bact. infec.
In the tmt. of pts. with bacteremia that occurs in associate. with, oris suspect. to be assoc. with, any of the infecs. listed above Ceftriaxone should be co-admin. with other antibact. agents whenever the possible range of causative bacteria would not fall within its spectrum.
C/I: Hypersens. History of severe hypersens. (e.g. anaphyl. react. ) to any other type of beta-lactam antibact. agent (penicillins, monobactams, carbapenems).
Premature neonates up to a postmenstrual age of 41 wks. (gestat. age+chronological age). Full-term neonates (up to 28 d of age): - with hyperbilirubinaemia, jaundice, or who are hypoalbuminaemic or acidotic because these are condit. in which bilirubin bind. is likely to be impair., if they require (or are expected to require) IV calcium tmt., or calcium-contain. infus. due to the risk of precip. of a ceftriaxone-calcium salt.
Contraindic. to lidocaine must be excluded before IM inj. of ceftriaxone when lidocaine sol. is used as a solvent.
Ceftriaxone sol. contain. lidocaine should never be admin. IV. See lit.