All the biological system drugs
serotonin releasing agent. Fenfluramine 2.2 mg/ml. Oral sol. 60,120,250,360 ml
Without concomitant stiripentol
Day 0: 0.1 mg/kg taken X 2/d
Day 7: 0.2 mg/kg X 2/d
Day 14: 0.35 mg/kg X 2/d
Max. recomm. daily dose: 26 mg (13 mg X2/d, i.e., 6.0 mL X 2/d)
With concomitant stiripentol (DS pts only)
Day 0 (Starting dose): 0.1 mg/kg taken X 2/d
Day 7: Maintenance dose of 0.2 mg/kg X 2/d
Day 14: Not applic.
Max. recomm. daily dose: 17 mg (8.6 mg X2/d, i.e., 4.0 mL X2/d)
Tmt. of seizures assoc. with Dravet syndr. and Lennox-Gastaut syndr. as an add-on ther. to other anti-epileptics for pts. 2 years of age and older
C/I: Hypersens/Aortic or mitral valvular heart disease/
Pulmonary arterial HT/ Within 14 days of the admin. of monoamine oxidase inhib. due to an incr. risk of serotonin syndr.
Antiepileptics. Cenobamate 12.5 mg, 25 mg, 50 mg, 100 mg, 200 mg. TABS + FC TABS. (combined pack): 12.5 mg X 14 + 25 mg X 14
FC TABS: 50/100/200 mg X 30
Adlts: recomm. start. dose is 12.5 mg /d, titr. grad. to the recomm. target dose of 200 mg/d. Based on clin. response, dose may be incr. to a max of 400 mg/d. See lit. for recommen. titrat. sched. which should not be exceeded because of potent. ser. adv. reactions.
For the adjunctive tmt. of focal-onset seizures with or w/o sec. generalisation in adlt. ptts. with epilepsy who have not been adeq. controlled despite tmt. with at least 2 anti-epil. medic. prod.
C/I: Hypersens. Familial Short-QT syndr.
See lit
