All the Active Ingredient Drugs
Antibiotics. Rifabutin 150 mg. HARD CAPS.: 30.
Gener. Admin. as a single, dly., oral
dose at any time independ. of meals.
Adult.: As monother.- Prophyl. of MAC
infect. in immune-depres. pts.: 300 mg
(2 caps.).
In comb. regimens: Non-tuberc.
mycobact. dis.: 450-600 mg (3 to 4
caps.) for up to 6 mnths. after negat.
cultures are obtained.
MAC tmt.: in comb. with clarithromycin,
the dosage of Rifabutin should be
reduced to 300 mg after the 1st month
of tmt.
Pulmon. tuberc.: 150 mg dly. (1
cap.), for 6-9 mnths., or for at least 6
mnths. after negat. cultures are
obtained. Should be incr. to 300-450
mg/d in pts. prev. treated with
antituberculous drugs.
Chron. tuberculosis where there is firm
evid. of acid fast bacteria resist. to
Rifampicin or to two other alternat.
drugs.
Tmt. of infect. caused by MAC or other
atyp. mycobact. where there is evid.
of resist. bacteria as above.
Tmt. of infect. caused by MAC or other
atypical mycobact. in AIDS pts. in all
cases not subject to the above
restrictions.
Prevent. of MAC infect. in AIDS pts. whose
CD4 counts are lower or equal to 200mm3.
C/I: hypersens. incl. to other rifamycins
(e.g. rifampicin). Pregn. & lact. Childr.
Concom. use with rilpivirine contain. prolonged-rel. suspens. for inject.
