Palonosetron

2 Drugs classified under this active ingredient

5-HT3 Antagonist, Selective Antagonist of NK1 Receptors. Netupitant 300 mg, Palonosetron (hydrochloride) 0.5 mg.
CAP.: 1. One 300 mg / 0.5 mg cap. should be administered approx. one h.  prior to the start of each chemother. cycle. The recommend. oral dexamethasone dose should be reduced by approx. 50 % when co-admin. with this formul.
Preven.of acute & delayed nausea and vomit. assoc.  with init. and repeat courses of cancer chemoth., includ., but not limited to, highly emetogenic chemother.
C/I: Hypersens., preg.

5-HT3 Antagonist. Palonosetron (as HCl) 0.25 mg/vial.
VIALS (sol. for inject.): 1 x 5 ml. 0.25 mg
I.V. as single dose over 30 secs. approx.
30 mins. bef. start chemo. Repeat.
dose within 7-day interval not
recommend. Not to be mixed with
other drugs. Flush infus. line with
normal saline bef. and aft. admin.
Elderly/ren./hep. impair: No dose
adjust.
Prevent chemo.-induced naus. and
vomit. (CINV).
C/I: Hypersens.