All the Active Ingredient Drugs
ALK, Tyrosine Kinase Inhibitor. Lorlatinib 25 mg, 100 mg. F.C. TABS.: 90, 120×25mg, 30×100mg. 100 mg×1/d orally, with/without food, at the same time each day, until dis. progress. or unacceptab. toxic.
Swallow tablets whole. If a dose is missed, then the missed dose should be taken, unless the next dose is due within 4 hrs. If vomit. occurs after lorlatinib cont. with the next scheduled dose. 2 doses should not be taken at the same time to make up for a missed dose. See lit.
Tmt. of pts. with anaplast. lymphom. kinase (ALK)-positive metast. NSCLC whose dis. has progressed on;
crizotinib and at least one other ALK inhib. for metast. dis.;
alectinib as the first ALK inhib. for metast. dis.;
ceritinib as the first ALK inhib. for metast. dis.
C/I: Pts. taking strong CYP3A induc., due to the potential for serious hepatotox. Hypers.