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  • Dacarbazine
    2 Drugs classified under this active ingredient

    All the Active Ingredient Drugs

    Dacarbazine Medac
    partial basket chart
    Dacarbazine Medac

    Alkylating Agent. Dacarbazine (as Citrate) 200, 500, 1000 mg/vial.
    SINGLE DOSE VIALS (Pwdr. for sol. for
    inject./infus.): 1, 10 x 200 mg; (Pwdr. for
    soln for infus.): 1, 10 x 500 mg, 1,000 mg.
    Malign. melanoma: (as single agent):
    200-250 mg/m2 bdy surface area/day)
    I.V. for 5 days every 3 wks. Alt: Shortterm
    infus. (over 15-30 mins). Also
    possible: I.V. 850 mg/m2 on day 1, then
    once every 3 wks. Hodgkin’s dis: 375
    mg/m2 I.V. every 15 days in comb. with
    doxorubicin, bleomycin and
    vinblastine. See lit.
    Malign. melanoma, Hodgkin’s dis.
    C/I: Hypersens., pregn., lact., leucopen.,
    and/or thrombocytopen., severe liver/
    kidney dis.

    partial basket chart

    Alkylating Agent. Dacarbazine 200 mg/vial.
    VIALS (pwdr. for reconstit.): 1 x 200 mg +
    19.7 ml water. I.V. inject.,/infus.
    Monother: 4-5 day cycles of 150-250
    mg/m² bdy surface/day. May repeat
    every 21 days. Alt. tmt: 2.0-4.5 mg/kg/
    day for 1-10 days. Can repeat every 28 days. Inject over ±1 min/infus. over
    15-30 mins. If necess. may be given I.A.
    Comb. chemother: 4-5 day cycles of
    100 mg/m²/day with 21 day intervals
    start. from last day tmt.
    Metastat. malign. melanoma, Hodgkin’s
    dis. as 2nd line ther. when used in comb.
    with other agents.
    C/I: Hypersens., ren. insuffic., bone
    marrow defic., pregn., lact.