Dacarbazine

2 Drugs classified under this active ingredient

Alkylating Agent. Dacarbazine (as Citrate) 200, 500, 1000 mg/vial.
SINGLE DOSE VIALS (Pwdr. for sol. for
inject./infus.): 1, 10 x 200 mg; (Pwdr. for
soln for infus.): 1, 10 x 500 mg, 1,000 mg.
Malign. melanoma: (as single agent):
200-250 mg/m2 bdy surface area/day)
I.V. for 5 days every 3 wks. Alt: Shortterm
infus. (over 15-30 mins). Also
possible: I.V. 850 mg/m2 on day 1, then
once every 3 wks. Hodgkin’s dis: 375
mg/m2 I.V. every 15 days in comb. with
doxorubicin, bleomycin and
vinblastine. See lit.
Malign. melanoma, Hodgkin’s dis.
C/I: Hypersens., pregn., lact., leucopen.,
and/or thrombocytopen., severe liver/
kidney dis.

Alkylating Agent. Dacarbazine 200 mg/vial.
VIALS (pwdr. for reconstit.): 1 x 200 mg +
19.7 ml water. I.V. inject.,/infus.
Monother: 4-5 day cycles of 150-250
mg/m² bdy surface/day. May repeat
every 21 days. Alt. tmt: 2.0-4.5 mg/kg/
day for 1-10 days. Can repeat every 28 days. Inject over ±1 min/infus. over
15-30 mins. If necess. may be given I.A.
Comb. chemother: 4-5 day cycles of
100 mg/m²/day with 21 day intervals
start. from last day tmt.
Metastat. malign. melanoma, Hodgkin’s
dis. as 2nd line ther. when used in comb.
with other agents.
C/I: Hypersens., ren. insuffic., bone
marrow defic., pregn., lact.