All the Active Ingredient Drugs
Antimetabolite (pyrimidine analog). Azacitidine 100 mg. VIAL:Pwder for susp. for inj./inf. 1 X 100 mg
First cycle:75 mg/m2 SC or IV, daily for 7 days.
Subsequent Cycles: Repeat cycles every 4 weeks. Dose may be incr. to 100 mg/m2 if no beneficial effect is seen after 2 cycles. It is recomm. that pts be treated for a min. of 4 to 6 cycles. See full prescript. info.
For pts with the following FAB myelodysplastic syndr. subtypes: refractory anemia or refractory anemia with ringed sideroblasts ( if accompanied by neutropenia or thrombocytopenia or requiring transfusions),refractory anaemia with excess blasts, refractory anaemia with excess blasts in transformation, and chronic myelomonocytic leukaemia.
C/I:Hypersens. Adv. malignant hepatic tumors.
Antimetabolite (pyrimidine analog). Azacitidine 100 mg. VIAL (Lyophilized pwdr. for suspens. for SC Inj./sol. for infus.): 1. 1st tmt. cycle, for all pts. regardless of baseline hematology lab. values, is 75 mg/m² SC or IV, daily for 7 d. Premedicate pts. for nausea & vomit.
Obtain complete blood counts, hep. enzym., serum creatinine prior to the 1st dose.
Subseq. Tmt. Cycles: Repeat cycles every 4 wks. The dose may be incr. to 100 mg/m² if no beneficial effect is seen after 2 tmt. cycles and if no toxicity other than nausea & vomit. has occurred. It is recomm. that pts. be treated for a min. of 4-6 cycles. However, complete or partial response may require addit. tmt. cycles. Tmt. may be continued as long as the pt. continues to benefit.
Tmt. of pts. with the following French-American-British (FAB) myelodysplastic syndr. subtypes: refract. anemia (RA) or refract. anemia with ringed sideroblasts (if accompan. by neutrop. or thrombocytop. or require. transfusions), refract. anemia with excess blasts (RAEB), refract. anemia with excess blasts in transformation (RAEB-T), and chron. myelomonocytic leukem. (CMMoL).
C/I: Hypersens. Pts. with advanced malig. hep. tumors.
Antimetabolite (pyrimidine analog). Azacitidine 100 mg. VIAL: 1 x 100 mg. 1st cycle: 75 mg/m²
S.C. dly for 7 days. Premed. for naus./
vomit. See lit for subseq. cycles.
Myelodysplastic syndr. subtypes. See lit.
C/I: Hypersens. to azacitidine or mannitol, advanced malign. hepat. tumors.
