Amisulpride

2 Drugs classified under this active ingredient

Atypical Antipsychotic. Amisulpride 100 mg, 400 mg.
F.C. TABS.: 30×100, 400mg: Predomin. neg. episodes: 50 mg/d- 300 mg/d Doses should be adjust. individ. The opt. dosage is about 100 mg/d. For pts. with mixed posit.& neg. symp.,doses should be adjust. to obtain opt. control of posit. symp. Acute psychot. episodes: Init. tmt.: It is poss. to start via the IM route for a few days, at a max. dose of 400 mg/d, switch. thereafter to oral tmt. Oral doses between 400 mg/d& 800 mg/d are recom. The  max. dose should never exceed 1200 mg. Given that there has been no large-scale safety assess. of doses> 1200 mg/d, these doses should not be used.
Tmt. of schizophrenia.
C/I: Hypersens. Presence of  pheochromocytoma. Pts. under 15 yrs. old. Lact. WOCBP, unless they are using proper contracept. Pts. with  prolactin-depend. tumor, e.g. pituit.  tumor/breast canc. Concom.  use with: anti- Parkinson. drugs  (e.g., amantadine, apomorphine, bromocriptine, entacapone, lisuride, pergolide, piribedil, pramipexole, rasagiline, ropinirole, rotigotine, selegiline). Concom. use with: drugs that affect heart rate(e.g., TdP),  class Ia antiarrhythmics, such as quinidine, hydroquinidine, disopyramide, and class III antiarrhythmics, such as amiodarone, dronedarone, sotalol, dofetilide, ibutilide). Concom. use with: chlorpromazine, cyamemazine, droperidol, flupenthixol, fluphenazine, haloperidol, levomepromazine, pimozide, pipamperone, pipotiazine, sertindole, sulpiride, sultopride, tiapride, zuclopenthixol). Concom. use with: halofantrine, lumefantrine, pentamidine, methadone. addiction to certain drugs. Concom.  use with: arsenic compounds, bepridil, cisapride, diphemanil, dolasetron IV, erythromycin IV, mizolastine, vincamine IV, domperidone, levofloxacin, mequitazine, vandetanib, moxifloxacin, spiramycin IV, toremifene, alcohol.

Atypical Antipsychotic. Amisulpride 100 mg, 400 mg.
TABS: 30x 100 mg, 400 mg.
Acute psychot.states: 400-800 mg dly.
predom. neg. states: 50-300 mg dly.
Adjust to optimum dose: 100 mg dly.
Elder.pts.: use with caution due to the
risk of hypotens., sedat.
Reduct. dosage may also be require.
due to renal insuffic. See lit.
Tmt. of schizophren.
C/I: Hypersens.,concom. use
dopamineagonists/ levodopa, known/
suspected prolactin depend. tumors,
known/ suspected pheochromocytoma
carriers.
Child. under 15 yrs, pregn., lact., WOCBP
unless using adeq. contracept. Severe
renal insuffic.Known or suspect.
prolactin-depend. tumors, e.g. prolactinsecret.
pituitary adenoma, breast cancer.
In comb.with: citalopram, escitalopram,
non-antiparkinsonian dopamine
agonists(cabergoline, quinagolide),
levodopa.