Vertex Pharmaceuticals (U.K.) Limited, Israel

Transmembrane Conductance Regulator Potentiator. Ivacaftor 50, 75, 150 mg.
SACHET (granules): 56×50, 75mg.
FILM COAT. TABS: 56×150mg. Pts. wt.<14 kg: 50 mg granules taken orally every 12 hrs. with fat contain. food total dly. dose 100 mg.
Pts.≥14 kg-<25 kg: 75 mg granules taken orally every 12 hrs. with fat-contain. food, total dly. dose 150 mg.
Pts. ≥25 kg: 150 mg tab. taken orally every 12 hrs. with fat-contain. food, total dly. dose 300 mg. See lit.
Tmt. of pts. with CF aged 6 yrs. and older and weighing 25 kg or more who have one of the follow. gating (class III) mutations in the CFTR gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N or S549R.
The granules are indic. for the tmt. of child. with CF aged 2 yrs. and older and weighing less than 25 kg who have one of the follow. gating (class III) mutations in the CFTR gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N or S549R.
C/I: Hypersens.