Drugs Disributed by Medomie Pharma Ltd, Israel
Glucocorticoid. Hydrocortisone 0.5 mg, 1 mg , 2 mg, 5 mg. Gran. in caps. for opening 50X0.5/1/2/5 mg. Recomm. doses: 8-10 mg/m2/day for pts. with adr. insuff. alone and 10-15 mg/m2/day in pts. with congen. adr. hyperpl. (CAH), in three or four div. doses. See prescr. inform.
Replac. ther. of adren. insuff. from birth to < 18 years old.
C/I:Hypersens., dysphagia, premature inf. where oral feed. has not been establ.
Fibrate. Bezafibrate 400 mg. SR Tab. 30 X 400 mg
One tablet, to be swallowed whole with suffic. fluid after a meal either in the
morning or at night.
Adjunct to diet and other non- pharmacological
tmt. (e.g. exercise, weight reduct.) for
the tmt. of sev. hypertriglyceridaemia
C/I: Hypersens. – Signif. hepatic dis. (other than fatty infiltr. of the liver assoc. with raised triglyceride values).
- Gall-bladder dis. with or without cholelithiasis.
- Pts. with nephrotic syndr. and sev. renal fail. (serum creatinine > 135μmol/l; creatinine clear.<60ml/min) and pts. undergoing dialysis.
- Combin. ther. (concom. use) of bezafibrate with HMG CoA reductase inhibit. (statins) in pts. with predisposing factors for myopathy.
- Known photoallergic or phototoxic reactions to fibrates.
Glucocorticoid. Hydrocortisone 5 mg, 10 mg. MR Caps.50, 100 X 5/ 10 mg
Tmt. should be initiated by physicians experienced in CAH. As maint. ther., dose must be individualised according to the resp. of the indiv. ptt. The lowest possible dose should be used. Monitoring is necessary and ptts. should be observed closely for signs that might require dose adjust., incl. changes resulting from remissions or exacerbations of the dis., changes in electrolytes particularly hypokalaemia, individual responsiveness, and the effect of stress (e.g. surgery, infection, trauma). Recommended replacement doses of hydrocortisone are 10-15 mg/m2/day in adolesc. aged 12 years and over who have not completed growth, and 15-25 mg/day in adolesc. who have completed growth and adlt pts. with CAH. See full prescription info.
Tmt. of congen. adrenal hyperplasia (CAH) in adolesc. aged 12 years and over and adults.
C/I: Hypersens.
