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  • Xylonor Epinephrine
    / A. Levy Dental Depot


    Active Ingredient *
    Lidocaine HCl 36 mg / 1.8 ml
    Adrenaline 22.5 mcg / 1.8 ml

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Cartridge (solution for injection)

    50 X 1.8 ml

    not in the basket chart

    Dosage

    Adults: A single cartridge is generally sufficient. Two are used in case of large interventions. However, three may be used if deemed necessary for prolonged procedures.
    Adolescents between 14 and 17, and the elderly: Usual dose 1.8 ml (1 cartridge). Do not exceed 3.6 ml (2 cartridges) in usual cases.
    Children between 6 and 14: Usual dose 1.35 ml (3/4 of a cartridge). Do not exceed 2.7 ml (1½ cartridge) in usual cases.
    Children between 3 and 6: 0.9 to 1.8 ml (½ to 1 cartridge).
    Do not use under 3 years of age.


    Indications

    For the production of local anesthesia for dental procedures by infiltration or nerve block injections.


    Contra-Indications

    Known history of hypersensitivity to local anaesthetics of the amide type or to any components of the injectable formulation.
    Due to the presence of a vasoconstrictor (adrenaline) in the formula, it is contra-indicated for patients suffering from: arterial hypertension coronary disease, valvular cardiac disease (particularly sequelae to acute rheumatic fever).


    Special Precautions

    Dental practitioners who employ local anaesthetic agents should be well  versed in diagnosis and management of emergencies which may arise from their use. Resuscitative equipment, oxygen and other resuscitative drugs should be available for immediate use.
    Do not use in bronchial asthmatics with hypersensitivity to sulfites. The reaction may be characterized by vomiting, diarrhea, dyspnea, acute asthma attacks, disorientation or shock.
    Do not inject into a blood vessel. Inject slowly.
    See prescribing information for full details. 


    Side Effects

    Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anaesthetic agents, these adverse experiences are, in general, dose-related and may result from high plasma levels caused by excessive dosage, rapid absorption or unintended intra-vascular injection, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Serious adverse experiences are generally systemic in nature.
    See prescribing information for full details.


    Drug interactions

    As in the case of all other local anaesthetic solutions containing, interactions with MonoAmine Oxidase Inhibitors, TriCyclic Antidepressants or Phenothiazines may produce severe prolonged hypotension or hypertension.
    Concurrent administration of vasopressor drugs and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. If sedatives are employed to reduce patient apprehension, reduced doses of anaesthetic solution.
    Concurrent use of beta-adrenergic blocking agents with an anaesthetic solution containing a vasoconstrictor, may result in dose dependent hypertension and bradycardia.
    See prescribing information for full details.


    Pregnancy and Lactation

    Pregnancy: On the basis of long usage, anaesthetics of the lidocaine type are considered reasonably safe for use on pregnant women. However, there is inadequate evidence of safety of lidocaine on foetal development.
    Lactation: It is not known whether this drug is excreted in human milk, because many drugs are excreted in human milk, caution should be exercised when lidocaine is administered to a nursing woman.
    See prescribing information for full details.              


    Overdose

    Acute emergencies from local anaesthetics are generally related to high plasma levels encountered during therapeutic use of excessive dosage of local anaesthetics, or to unintended intravascular injection of local anaesthetic solution.  


    Important notes

    StorageStore under 25°C, do not freeze.

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