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    / Unipharm

    Active Ingredient

    Status in Israel

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft


    30 X 200 mg

    full basket chart 1781 16237

    Related information


    Initial dose is 600 mg daily, maintenance dose is 200-400 mg daily with or after meals. Please refer to the license holder for further details.                   


    Treatment of cardiac arrhythmias and coronary arterial insufficiency.


    Sensitivity to amiodarone hydrochloride or to any of the other ingredients contained in the medicine, or to iodine. Symptoms of an allergic reaction including rash, difficulty swallowing or breathing, swelling of the lips, face, throat or tongue. Pregnancy or breastfeeding. Thyroid dysfunction. Arrhythmias manifested mainly by slow heartbeats (sinus bradycardia) or from an arrhythmia called sino-atrial heart block. Arrhythmias and do not have an implanted pacemaker. Usage in combination with medicines that may cause arrhythmias.
    Please refer to the license holder for further details.

    Special Precautions

    If the patient suffers or has suffered in the past from impaired function of the respiratory system (e.g., asthma), heart (e.g., heart failure), vascular system, liver, eyes (including an illness called optic neuritis). Hypertension. The patient is about to undergo an operation (including dental) or any other procedure requiring anesthesia. The patient is 65 years of age or older (it is possible that more close medical supervision will be required). The patient has an implanted pacemaker or defibrillator. The doctor may check to make sure that the device is working properly after beginning treatment with the medicine or if the dosage is changed. The first stage of treatment (when taking the initial dosage) must be under close medical supervision.
    Use of this medicine may cause blurred vision. In such a case, treatment should be stopped and the patient should refer to the doctor immediately. During treatment with this medicine, the following tests should be performed: blood tests to rule out hypokalemia, function of the liver, thyroid, lungs (also before initiating treatment), routine eye examinations including fundoscopy, ECG.
    Please refer to the license holder for further details.

    Side Effects

    Most common side effects: Yellowing of skin or eyes (jaundice), fatigue or feeling ill, loss of appetite, stomach pain or high fever, difficulty breathing or a feeling of tightness in the chest, persistent cough, wheezing, weight loss and fever. Blurred vision, restlessness, weakness, Blue or grey marks on parts of the skin that were exposed to sunlight, especially on the face.
    Please refer to the license holder for further details.

    Drug interactions

    Additional medicines for arrhythmia such as sotalol, procainamide,
    disopyramide or bretylium. Medicines for treating infections such as intravenous erythromycin, co-trimoxazole, moxifloxacin or pentamidine. Medicines used to treat schizophrenia, such as chlorpromazine, thioridazine, fluphenazine, pimozide, haloperidol, amisulpride or sertindole. Medicines for additional psychiatric illnesses such as lithium, doxepin, maprotiline or amitryptyline.
    Medicines for treating malaria such as quinine, mefloquine, chloroquine or halofantrine. Medicines for treating hay fever, rash and other allergies, called antihistamines, e.g., terfenadine, astemizole or mizolastine. Medicines for treating infections, e.g. ciprofloxacin, ofloxacin or levofloxacin. Medicines for heart disease called beta blockers, e.g. propranolol. Medicines called calcium channel blockers (used to treat angina pectoris or hypertension), e.g. diltiazem or verapamil. Medicines to treat constipation (laxatives) e.g. bisacodyl or senna. Medicines to reduce cholesterol (statins), e.g. simvastatin or atorvastatin.
    The following medicines may increase the risk of side effects when taken together with the drug: Intravenous amphotericin B (for treating fungal infections). Steroidal anti-inflammatory medicines e.g., hydrocortisone, betamethasone or prednisolone. Diuretics. General anesthetics or oxygen at high dosages (used during surgeries). Tetracosactide – a medicine for certain hormonal problems.
    The drug may increase the effect of the following medicines: Cyclosporin and tacrolimus, used for preventing transplant rejection. Medicines to treat impotence, such as sildenafil, tadalafil or vardenafil. Fentanyl (to alleviate pain). Ergotamine (for treating migraine).  Midazolam (for treating anxiety or for tranquilizing before surgery). Flecainide (additional medicine for arrhythmia). Lidocaine (for local anesthetic) Please refer to the license holder for further details.
    Hepatitis C medicines: Harvoni (sofosbuvir with ledipasvir) // a combination of Sovaldi (sofosbuvir) // Daklinza (daclatasvir) Cases of severe, life-threatening symptomatic bradycardia have been reported.
    Please refer to the license holder for further details.

    Pregnancy and Lactation

    Pregnancy: The medicine should not be used without consulting the doctor before beginning treatment if the patient is pregnant or planning to become pregnant. Usually, this medicine is not given to pregnant women.
    Lactation: This medicine should not be used if the patient is nursing or planning to nurse, since small amounts of the medicine pass into breast milk.
    Please refer to the license holder for further details.


     Please refer to the license holder for further details.

    Important notes

    This medicine contains lactose that may cause an allergic reaction in people who are sensitive to lactose. Each tablet contains 200 mg of lactose.
    This medicine contains iodine which may cause thyroid problems.
    Patient should avoid exposure to the sun.
    Patient should limit alcohol consumption.
    This medicine may cause blurring of vision.
    Please refer to the license holder for further details.

    Trima Israel Pharmaceutical Products Maabarot Ltd. Israel