Deprexan

/ Unipharm

Adults: 100-200 mg per day. Up to a maximum of 300 mg, once a day.
Elderly and adolescents: 25-100 mg per day.
See prescribing information for full details.

Depression and melancholy conditions with or without underlying anxiety or agitation.

Known hypersensitivity to tricyclic antidepressants. Concomitant administration with monoamine oxidase inhibitors, or within 14 days after their discontinuation. Tricyclic antidepressants should not be used during the acute recovery phase following myocardial infarction.

Pregnancy and lactation, pediatrics, manic depressive patients.
Prescriptions should be written for the smallest quantity feasible.
Patients with cardiovascular disorders, blood pressure problems.
Caution against engaging in potentially hazardous occupations requiring mental alertness.
Elderly patients, patients with a history of urinary retention, angle-closure glaucoma, or increased intraocular pressure, given with anticholinergic or sympathomimetic drugs, hyperthyroid patients, or those receving thyroid medication, history of seizure disorders.
Avoid excessive exposure to sunlight.
Discontinue the drug for as long as is clinically feasible prior to elective surgery.

Dryness of the mouth, blurred vision, disturbances of accomodation, constipation, urinary retention and aggravation of angle-closure glaucoma, drowsiness, confusional states, hallucinations, disturbed concentration, peripheral neuropathy, fine tremor, seizures, extrapyramidal symptoms. Paradoxical reactions include anxiety and insomnia, allergic skin reactions and photosensitivity, rare cases of agranulocytosis, leukopenia, leukocytosis, eosinophilia and thrombocytopenia, heartburn, nausea, vomiting, unpleasant taste, diarrhea, anorexia, cholestatic jaundice, testicular swelling and gynecomastia in the male, breast enlargement and galactorrhea in the female, increased or decreased libido, alopecia, edema, weight gain or loss, urinary frequency, increased perspiration, increases or decreases in blood glucose levels.

MAOIs, directly acting sympathomimetics, antihypertensives, phenothiazines, anticholinergics, anticonvulsants. Alcohol, antihistamines, CNS depressants, benzodiazepines, opiate analgesics, cimetidine, phenytoin. Barbiturates, disulfiram, sublingual glyceryl trinitrate, thyroxine, acetazolamide. Zopiclone, high fibre diet, neuroleptics, SSRIs.