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  • Ciloxan
    / Novartis


    Active Ingredient
    Ciprofloxacin (as HCl) 3 mg/ml

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Eye Drops

    5 ml

    partial basket chart 8860 3033

    Dosage

    Ocular use: Adults, newborn infants (0-27 days), infants and toddlers (28 days to 23 months), children (2-11 years) and adolescents (12 — 16 years): Corneal ulcers: Must be administered in the following intervals, even during night time: On the 1st day: instil 2 drops into the affected eye every 15 minutes for the first six hours; and then 2 drops into the affected eye every 30 minutes for the remainder of the day. On the 2nd day: instil 2 drops into the affected eye hourly. On the 3rd through the 14th day, put two drops in the affected eye every 4 hours. If treatment is to surpass 14 days, the quantities can be adapted to the wishes of the attending physician.
    Superficial bacterial infections of the eye and its adnexa: For the first 2 days instil 1 or 2 drops into the conjunctival sac of the infected eye(s) every 2 hours while awake. Then 1 or 2 drops every 4 hours while awake until the bacterial infection is resolved.
    Otic use: Adults and children 1 year and above: First thoroughly clean the external auditory duct. lt is more agreeable to administer the solution at room temperature and better still at body temperature to prevent vestibular stimulation. Instil the product into the external ear duct as follows: 3 to 4 drops, two to four times per day, or more frequently, if required. The patient should first lie on the opposite side in relation to the affection and should preferably remain lying in this position for five to ten minutes. After local cleaning, an impregnated tent of gauze or a hydrophylic tent of cotton can also be inserted in the ear duct, and is generally left in place for one to two days, but should be impregnated to saturation with the product two times per day. In general, the duration of treatment does not exceed five to ten days. Sometimes, the treatment can be prolonged, but in those cases it is best the susceptibility of the loc& flora be established. As with all antibacterial preparations, prolonged use may lead to overgrowth with non-susceptible micro-organisms or fungi. For either indication a maximum duration of therapy of 21 days is recommended.


    Indications

    Corneal ulcers and conjunctivitis caused by susceptible gram positive and gram negative microorganisms for adults and pediatric patients above the age of 1 year. For localized or diffuse otitis externa accompanied by a strong inflammatory reaction and of which the strains are susceptible to ciprofloxacin, and for the acute flare-up of a chronic otitis media. In this case, a mucopurulent secretion comes through the perforated eardrum. Pseudomonas aeruginosa is one of the organisms most likely to be found in this case. Also in other infections of the ear in which Pseudomonas aeruginosa and/or other susceptible strains may be demonstrated or suspected (for example with suppurating tympanic tubes), Ciloxan can be used under the strict supervision of an ear specialist. It must be understood that this is not a routine treatment and that improper use must be avoided.


    Contra-Indications

    Hypersensitivity to the active substance or to any of the excipients. Hypersensitivity to quinolones.


    Special Precautions

    See prescribing information for full details.


    Side Effects

    With otic use the ingredients are rarely sensitizing. An allergic reaction to any of the ingredients can occur. Dermatitis, nausea and taste perversion. For full details see prescribing information.


    Drug interactions

    Specific studies with regard to the interactions were not conducted for ophthalmologic ciprofloxacin. It was however demonstrated that the systemic administration of certain quinolones increased the plasma concentrations of theophylline, had an influence on the metabolism of caffeine, and intensified the action of the oral anticoagulant warfarin and its derivatives. A temporary increase of creatinine in the serum was reported in patients who concomitantly received cyclosporin and systemic ciprofloxacin. If supplementary eye preparations are to be used, one should wait about 15 minutes between two applications.


    Pregnancy and Lactation

    Pregnancy: As there are no controlled studies in pregnant women, this product should be used during pregnancy only if the benefit justifies the possible risk for the foetus.
    Lactation: The excretion of ciprofloxacin in human milk after topical administration in the eye has not been studied. Therefore caution should be observed when used while breast-feeding.


    Overdose

    In case of topical overdose, eliminate the overdose with tepid water.


    Manufacturer
    Alcon
    Licence holder
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