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  • SNRI
    9 Drugs classified under this drug class


    All the Drug Class Drugs

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    Cymbalta
    Eli Lilly
    RX
    partial basket chart
    Cymbalta

    SNRI. Duloxetine HCl 30 mg, 60 mg.
    CAPS: 7,14,28 x 30 mg, 60 mg.
    intial: 30 mg dly. maint: 60 mg dly.
    Ther. response: 2-4 wks aft. tmt. To
    discont: Taper by 1/2 dose (30 mg) dly
    or on alt. days. See lit.
    Major depress. episodes., Generalized
    anxiety dis., Neuropath. pain assoc.
    with diabet. periph. neuropathy.,
    fibromyalg., chron. muscoskeletal pain.
    C/I: Concom. use with MAOI,
    uncontrolled narrow-angle glaucoma.

    Duloxetine DR Teva
    Teva
    RX
    partial basket chart
    Duloxetine DR Teva

    SNRI. Duloxetine (as HCl) 20, 30, 60 mg.
    DR CAPS: 30 ×20mg, 30mg, 60mg.
    Major depres.disor. 60 mg/d.
    GAD: init. reccom. dose 30 mg ×1/d for
    1 week, may be incr. to 60 mg ×1/d.
    Max until: 120mg x 1/d.
    Diab. periph. neurop. pain: 60 mg x
    1/d; lower init., dose, grad. incr. in pts.
    with ren. impair.
    Fibromyal.: init. 30 mg x 1/d; for 1
    week, may be incr. to 60 mg ×1/d.
    Chron. musculoskel. pain: init. 30 mg
    start at 30 mg ×1/d for 1 week, may be
    incr. to 60 mg ×1/d.
    Tmt. of Major. depress. epis.; manag. of
    neurop. pain assoc. with diab. periph.
    neurop. Tmt. of GAD; Fibromyal.; Manag.
    of chron. muscoskel. pain when other ther.
    have fail.or are contra-ind.
    C/I: Hypersens. , Liver dis. result. in hep.
    impair., Sev. ren. impair., Pts. und. other
    medic. contain. duloxetine.
    Concom. use with MAOIs or within 14 d.
    after use MAOIs Init. of tmt. with MAOIs
    should be start. only on a 5th day elapse
    from stop. tmt. with Duloxetine.
    Concom. use with fluvoxamine,
    thioridazine, cimetidine, quinolone.
    Concom. use with ciprofloxacin or
    enoxacin Pts. with uncontr. narr.-ang.
    glauc.

    Efexor XR
    Pfizer
    RX
    partial basket chart
    Efexor XR

    SNRI. Venlafaxine (HCl) 75 mg, 150 mg.
    E.R CAPS.: 28. Major depress. Episodes: The recomm. starting dose for prolong. release venlafaxine is 75 mg×1/d. Pts. not respond. to the init. 75 mg/d dose may benefit from dose incr. up to a max. dose of 375 mg/d. Dosage incr. can be made at interv. of 2 wks. or more. If clinic. warranted due to sympt. sever., dose incr. can be made at more freq. interv., but not less than 4 d. Contin. for at least 6 mnths. follow. remiss.
    GAD: The recomm. starting dose for prolong. rel. venlafaxine is 75mg×1/d. Pts. not respond. to the init. 75 mg/d dose may benefit from dose incr. up to a max. dose of 225 mg/d. Dosage incr. can be made at interv. of 2 wks. or more.
    SAD: The recomm. dose for prolong. rel. venlafaxine is 75mg×1/d. There is no evidence that higher doses confer any addit. benefit.
    However, in individ. pts. not respond. to the init. 75 mg×1/d, incr. up to a max. dose of 225 mg/d may be consid. Dosage incr. can be made at interv. of 2 wks. or more.
    For the tmt. of depress. Mainten. of recur. depress. Generalized anxiety Disord. (GAD) - short term & long-term. Social anxiety Disord. (SAD).
    C/I: Hypersens. Concom. tmt. with irrevers. MAOIs. Venlafaxine must not be initiat. for at least 14 d after discont. of tmt. with an irrevers. MAOI. Venlafaxine must be discont. for at least 7 d before starting tmt. with an irrevers. MAOI.

    Ixel
    Perrigo
    RX
    partial basket chart
    Ixel

    SNRI. Milnacipran (HCl) 25 mg, 50 mg.
    CAPS: 14,28,56,112. 100 mg in 2 div.
    doses.
    Tmt. of major depress. epis. in adult.over
    18 yrs. old.
    C/I: Hypersens. Concom. use with nonselec.
    MAOIs , B selec. MAOIs, digitalis , 5
    HT1D agon. Sev. card. impair.,
    arrhythmia (e.g. sign. left ventr. dysfunc.,
    NYHA Class III/IV), uncontr. hypertens.,
    sev., unst. coron. heart dis., lact. General.
    shouldn’t be use concom. with
    epinephrine, norepinephrine by parent.
    route, clonidine , related comp. and A
    selec. MAOIs.Prost.hypertrop., other gen.
    urin. disor. Preg.

    Venla
    Unipharm
    RX
    partial basket chart
    Venla

    SNRI. Venlafaxine (as HCl) 37.5 mg, 75 mg.
    TABS: 28. 2 tabs dly.
    Depression.
    C/I: Hypersens., pregn., lact., concur. use
    MAOI’s. See lit.

    Venlafaxine XR Teva
    Teva
    RX
    partial basket chart
    Venlafaxine XR Teva

    SNRI. Venlafaxine (HCl) 75, 150 mg.
    E.R. TABS: 30. Initial: 75 mg dly in single
    dose; for non-responders: Incr. up to
    225 mg dly in dly increments of up to
    75 mg at intervals of not less than 4
    days. Re-ass. regular. to evaluat.
    benefit of long term ther. Hepat.
    impair: Reduce init. dose by 50%. Ren.
    impair: Reduce total dly dose by
    25-50%. Pts. on hemodialys: Reduce by
    50%, withhold until dialys. tmt
    complet. (4 hrs). Elderly: No dos. adjust. needed. Care when incr. dose. Maint./
    extend. tmt: Perform period. evaluat.
    Discont: Taper grad., monitor pt.
    Switch. to/from MAOI: Allow at least 14
    days between discont. MAOI and
    initiat. of ther. Allow at least 7 days of
    discont. ther. bef. start tmt. with MAOI.
    Tmt. depress., maint. recurr. depress,
    GAD, short/long term SAD.
    C/I: Known hypersens., concom. use
    with MAOIs.

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