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  • SNRI
    9 Drugs classified under this drug class


    All the Drug Class Drugs

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    Cymbalta
    Eli Lilly
    RX
    partial basket chart
    Cymbalta

    SNRI. Duloxetine HCl 30 mg, 60 mg.
    CAPS: 7,14,28 x 30 mg, 60 mg.
    intial: 30 mg dly. maint: 60 mg dly.
    Ther. response: 2-4 wks aft. tmt. To
    discont: Taper by 1/2 dose (30 mg) dly
    or on alt. days. See lit.
    Major depress. episodes., Generalized
    anxiety dis., Neuropath. pain assoc.
    with diabet. periph. neuropathy.,
    fibromyalg., chron. muscoskeletal pain.
    C/I: Concom. use with MAOI,
    uncontrolled narrow-angle glaucoma.

    Dulox Teva 30 & 60 mg
    Abic
    RX
    partial basket chart
    Dulox Teva 30 & 60 mg

    SNRI. Duloxetine 30 , 60 mg.
    CAPS.:30. For diabet. peripher. neuropath.  pain: The usual dose is 60 mg ×1/d.
    For chron. musculoskel. pain and general. anxiety disord.: For most pts.
    60 mg ×1/d. Some pts. require an init. dose of Dulox Teva 30 mg ×1/d for one wk., and then the usual dose of
    60 mg ×1/d.
    For depression: Most pts. will receive 60 mg ×1/d. Some pts. require an init. dose of Dulox Teva 30 mg ×1/d for one wk., and then the usual dose of 60 mg ×1/d
    Elderly – The init. dose of 30 mg ×1/d for two wks., and only then consider incr. the dose to 60 mg ×1/d.
    Fibromyalgia: The init. dose of Dulox Teva is 30 mg ×1/d  for one wk., and then the usual dose of 60 mg ×1/d. In most cases, the effect of medication ther. with Dulox Teva is noticeab. after 2-4 wks. of tmt.
    See lit.
    Tmt. of major depressive episodes.
    Managem. of neuropath.pain associat. with diabet. peripher. neuropathy.
    Tmt. of generaliz. anxiety disord. (GAD).
    Manag. of fibromyalgia.
    Manag. of chron. muscoskel. pain when other therapies have failed or are
    contraindic. This has been establish. in studies in pts. with chron. low back pain (CLBP) and chron. pain due to osteoarthritis.
    C/I: Hypersens.
    Pts. with hep. dis.
    Pts.  with severe ren. dis..
    Concom. use with MAOI  includ. IV methylene blue and the antibiot.linezolid. MAOI should be discount. 14 d. before init.of the tmt. with duloxetine.
    Initiat. of MAOI should be start. at least 5 d. after discount. of the tmt. with duloxetine.
    Concom. use with thioridazine

    Efexor XR
    Pfizer
    RX
    partial basket chart
    Efexor XR

    SNRI. Venlafaxine (HCl) 75 mg, 150 mg.
    E.R CAPS.: 28. Major depress. Episodes: The recomm. starting dose for prolong. release venlafaxine is 75 mg×1/d. Pts. not respond. to the init. 75 mg/d dose may benefit from dose incr. up to a max. dose of 375 mg/d. Dosage incr. can be made at interv. of 2 wks. or more. If clinic. warranted due to sympt. sever., dose incr. can be made at more freq. interv., but not less than 4 d. Contin. for at least 6 mnths. follow. remiss.
    GAD: The recomm. starting dose for prolong. rel. venlafaxine is 75mg×1/d. Pts. not respond. to the init. 75 mg/d dose may benefit from dose incr. up to a max. dose of 225 mg/d. Dosage incr. can be made at interv. of 2 wks. or more.
    SAD: The recomm. dose for prolong. rel. venlafaxine is 75mg×1/d. There is no evidence that higher doses confer any addit. benefit.
    However, in individ. pts. not respond. to the init. 75 mg×1/d, incr. up to a max. dose of 225 mg/d may be consid. Dosage incr. can be made at interv. of 2 wks. or more.
    For the tmt. of depress. Mainten. of recur. depress. Generalized anxiety Disord. (GAD) - short term & long-term. Social anxiety Disord. (SAD).
    C/I: Hypersens. Concom. tmt. with irrevers. MAOIs. Venlafaxine must not be initiat. for at least 14 d after discont. of tmt. with an irrevers. MAOI. Venlafaxine must be discont. for at least 7 d before starting tmt. with an irrevers. MAOI.

    Ixel
    Perrigo
    RX
    partial basket chart
    Ixel

    SNRI. Milnacipran (HCl) 25 mg,.
    CAPS: 56. 100 mg in 2 div. doses.
    Tmt. of major depress. epis. in adult.over
    18 yrs. old.
    C/I: Hypersens. Concom. use with nonselec.
    MAOIs , B selec. MAOIs, digitalis , 5 HT1D agon. Sev. card. impair., arrhythmia (e.g. sign. left ventr. dysfunc., NYHA Class III/IV), uncontr. hypertens., sev., unst. coron. heart dis., lact. General. shouldn’t be use concom. with epinephrine, norepinephrine by parent. route, clonidine , related comp. and A selec. MAOIs.Prost.hypertrop., other gen.urin. disor. Preg.

    Miln-Avenir
    BioAvenir Ltd.
    RX
    not in the basket chart
    Miln-Avenir

    SNRI. Milnacipran 25 mg, 50 mg.
    CAPS 14, 28, 56 x 25 mg , 14, 28, 56 x 50 mg. Usual dose: 1 caps. of 50 mg in the morning and 1 caps. of 50 mg in the evening. For tmt. of depress. in adlts. above the age of 18 years.
    C/I: •  hypersens. • associat. with irreversible MAO inhibit., B selective MAO inhibit., digitalis and 5HT1D agonists (sumatriptan, etc.)• lactation
    • uncontr. hypertens., sev. or unstable coron. heart dis. as these underlying condit. may be comprom. by incr. in blood press. or heart rate. • In assoc. with epinephrine and norepinephrine by parent. route, clonidine and rel. compounds and A select. MAO inhib.
    • Prostatic hypertr. and other genito-urinary disord.

    Venla
    Unipharm
    RX
    partial basket chart
    Venla

    SNRI. Venlafaxine (as HCl) 37.5 mg, 75 mg.
    TABS: 28. 2 tabs dly.
    Depression.
    C/I: Hypersens., pregn., lact., concur. use
    MAOI’s. See lit.

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