All the Drug Class Drugs
Progestagens & estrogens. Estradiol , Dydrogesterone . TABS.: 28. (14 white tabs. 1 mg estradiol & 14grey tabs. contain.1 mg estradiol &10 mg dydrogesterone).
For each cycle of 28 d. for the first 14 d. one white tab. with estradiol is taken once dly. and for the follow. 14 d. one grey tab. with estradiol & dydrogesterone is taken once dly., as indicated on the calendar pack for 28 d.
After a cycle of 28 d. ays on the 29th day a new cycle of 28 days begins. The tmt. cycles therefore follow one another without a break.
For the tmt. of estrogen defic. in postmenopaus. women as an init. and mainten. dose the lowest effective dose should be used and the duration of tmt. period should be kept as short as possible. In case of no improve. of sympt. within 3 mnths., tmt. should be stopped.
In general sequent.ial combined tmt. should be started with Femoston 1/10 mg.
Depend. on the clinical response the dose can be adjust. accordingly. See lit.
Hormone replacement ther.(HRT) for estrogen defic. sympt. in postmenopaus. women at least 6 mnths. since last menses.
Prevent. of osteoporosis in postmenopaus. women at high risk of future fractures. Femoston 1/10 mg should only be used in pts. who are intoler.of other products, approved for the prevent. of osteoporosis or for whom these products are contra-ind.
Femoston is indic. for women with an intact uterus.
Experience with tmt. of women >65 yrs. is limited.
Presence/ suspic.of breast cancer; hist. of breast canc.
Presence / suspic. of estrogen-sensit. tumours (e.g.endometrial cancer).
Vag. bleed. of which the cause has not been determined;
Untreated endometr. hyperplasia;
History of active venous thromboembolism (DVT, PE).
Presence of a thrombophilic condit. (e.g. protein C, protein S or antithrombin defic.
Active or recent arterial thromboembolic dis.(angin. pectoris, MI).
Acute hep. dis. or history of hep. dis. as long as the liver funct. values have not returned to normal.