Nitrogen mustard analogues

1 Drug classified under this drug class

Nitrogen mustard analogues. Bendamustine Hydrochloride 25,100 mg.
VIAL(Pwdr. for concentrate for sol. for IV infus.):1×25,100 mg.
Monother. for CLL 100 mg/m² bdy. surface area bendamustine HCl on days 1 and 2; every 4 wks. up to 6 times.
Monother. for indolent non-Hodgkin’s lymphomas refract. to rituximab
120 mg/m² bdy. surface area bendamustine HCl on days 1 and 2;
every 3 wks. for at least 6 times.
Follicular non-Hodgkin’s lymphoma: Comb. with rituximab
The dose is 90 mg/m² body surface area bendamustine HCl on days 1 and 2
plus 375 mg/m² rituximab on day 1; repetition every 4 wks. See lit.
1^st -line of CLL (Binet stage B or C) in pts. for whom fludarabine comb. chemother. is not appropiate. Indolent non-Hodgkin’s lymphomas as monother.in pts., who have progress. during or within 6 mnths. follow. tmt. with rituximab or a rituximab contain. regimen. Follicular non-Hodgkin’s lymphoma as 1^st  line tmt. in comb. with rituximab.
C/I: Hypersens.
Lact.
Sev. hep. impair. (serum bilirub. > 3.0 mg/dl).
Jaundice.
Severe bone marrow suppres. and severe blood count alterations (leukocyte and/or platelet values dropped to < 3,000/μl or < 75,000/μl, respectively).