All the Drug Class Drugs
Growth Hormone Receptor Antagonist. Pegvisomant 10, 15, 20, 25, 30 mg. VIALS: 30 x 10 mg/ml, 15 mg/ml, 20 mg/
ml. A load. dose of 40-80 mg should be
admin. SC. Dose adjust. should be
based on serum IGF-I levels. Serum
IGF-I concentrations should be
measured every 4-6 wks. and
appropriate dose adjust. made in
increments of 5 mg/d in order to
maint. the serum IGF-I concent. within
the ageadjust. normal range, to maint.
an optimal therapeut. response, and
alleviate the signs and the sympt. of
acromegaly. Max. dose should not
exceed 30 mg/d. See lit.
Tmt. acromegaly in whom inad.
response to surg. and/or radiat. ther. and
in whom appropriate medical tmt. with
somatostatin analog did not normalize
IGF-I concentrats. or was not tolerated.