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  • Growth Hormone Receptor Antagonist
    1 Drug classified under this drug class

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    partial basket chart

    Growth Hormone Receptor Antagonist. Pegvisomant 10, 15, 20, 25, 30 mg.
    VIALS: 30 x 10 mg/ml, 15 mg/ml, 20 mg/
    ml. A load. dose of 40-80 mg should be
    admin. SC. Dose adjust. should be
    based on serum IGF-I levels. Serum
    IGF-I concentrations should be
    measured every 4-6 wks. and
    appropriate dose adjust. made in
    increments of 5 mg/d in order to
    maint. the serum IGF-I concent. within
    the ageadjust. normal range, to maint.
    an optimal therapeut. response, and
    alleviate the signs and the sympt. of
    acromegaly. Max. dose should not
    exceed 30 mg/d. See lit.
    Tmt. acromegaly in whom inad.
    response to surg. and/or radiat. ther. and
    in whom appropriate medical tmt. with
    somatostatin analog did not normalize
    IGF-I concentrats. or was not tolerated.
    C/I: Hypersens.