All the Drug Class Drugs
Gonadotropin. Urofollitropin (FSH) 75 IU/vial. VIAL (pwdr. for inject. + amp with solv.):
10. For S.C. inject. See lit.
Anovulatory infertility (incl. PCOD),
unresponsive to clomiphene citrate.
Controlled ovarian hyperstim. to induce
develop. multiple follicles for ART, such as
IVF, ET, GIFT and ICSI.
C/I: Tumors of pituitary/hypothalam.
glands, ovarian, uterine or mammary
carcinoma. Pregn., lact. Gyn. hemorrh. of
unknown etiology. Hypersens.
Gonadotropin. Corifollitropin Alfa 100 mcg / 0.5 ml. PREFILL. SYR: 1. Bdy wt. ≤ 60 kg: 100 μg;
bdy wt. ≥ 60 kg: 150 μg, both as single
doses. See lit.
COS in combinat. with GnRH antagonist
for develop. multiple follicles in women
participating in an ART program.
C/I: Hypersens., tumors of ovary, breast,
uterus, pituitary, hypothalamus,
unknown/undiagn. abnorm. vag. bleed.,
prim. ovarian fail., ovarian cysts/
enlarged ovaries, history OHSS, previous
COS cycle with > 30 follicles >11 mm,
basal antral follicle count > 20, fibroid
tumors of uterus incompatible with
pregn., malformats. reproduct. organs.
See lit.
Gonadotropin. Corifollitropin Alfa 150 mcg / 0.5 ml. PREFILL. SYR: 1. Bdy wt. ≤ 60 kg: 100 μg;
bdy wt. ≥ 60 kg: 150 μg, both as single
doses. See lit.
COS in combinat. with GnRH antagonist
for develop. multiple follicles in women
participating in an ART program.
C/I: Hypersens., tumors of ovary, breast,
uterus, pituitary, hypothalamus,
unknown/undiagn. abnorm. vag. bleed.,
prim. ovarian fail., ovarian cysts/
enlarged ovaries, history OHSS, previous
COS cycle with > 30 follicles >11 mm,
basal antral follicle count > 20, fibroid
tumors of uterus incompatible with
pregn., malformats. reproduct. organs.
See lit.
Gonadotropin. Urofollitropin 75 IU/vial, 150 IU/vial. VIAL (pwdr): 1 x 1 ml x 75 IU; 10 x 1 ml x
75 IU, 150 IU. All + solv. for sol. for inject.
Can be admin. dly. See lit.
Tmt. with FSH foll. by admin HCG to
induce ovulat. in infertile women
suffering from hypothal./hypophyseal disords., spanomenorrheic/amenorrheic
women. See lit.
C/I: Pregn., lact., hypersens., enlarged
ovaries/cysts not caused by hormonal
disord., bleed. of unknown cause, cancer
ovaries/uterus/breast, abnorm. swell.
pituitary/hypothal., early menopause,
malformat. sex. organs/tumors of womb
that make norm. pregn. impossib. See lit.
Gonadotropin. Follitropin Alfa 600 IU/ml. PRE-FILLED PEN: Follitropin alfa 600 IU/
ml (eq. 44 μg/ml) for S.C. inj. 1 x 300 IU (eq. to 22
μg)/0.5ml; 1 x 450 IU (eq. to 33 μg)/0.75ml
1 x 900 IU (eq. to 66 μg)/1.5ml.
Women with anovul. (incl. polycystic ovar. syndr.):
Admin. as a course of daily inject. In menstr. women tmt. should start within the first 7 days of cycle. Common regim. starts at 75 to 150 IU FSH daily and is incr. prefer. by 37.5 or 75 IU at 7- or prefer. 14-days intervals if necessary, to obtain an adeq., but not excess., response. Tmt. should be tailored to patient's respon. by measur. follicle size by US and/or estrog. secret. The max. daily dose is usually not higher than 225 IU FSH. See prescr. details
Women undergoing ovar. stimul. for mult. follicular develop. prior to IVF or other assisted reprod. techn.:
Common regim. for superovul. is 150 to 225 IU/d, start on days 2 or 3 of cycle. Tmt. is cont. until adeq. follicular dev. (as by US and/or serum estrogen concentr.) achieved, with dose adjust. to patient's resp., to usually not higher than 450 IU/d. See prescr. details.
Women with anovul. result. from sev. LH and FSH defic.:
In LH and FSH defic. women (hypogonadotrophic hypogonadism), the object. of this ther. in assoc. with lutropin alfa is to develop single mature Graafian follicle from which the oocyte will be liberated after administr. of human chorionic gonadotrophin (hCG). This tmt. should be given as a course of daily inject. simultan. with lutropin alfa. Since pts. are amenorrhoeic and have low endogen. estrogen secret., tmt. can commence any time. Recommend. regimen starts at 75 IU of lutropin alfa daily with 75 to 150 IU FSH. Tmt. should be tailored to ptt's respon. by measur. follicle size by US and estrog. respon. See prescr. details.
Men with hypogonadotrophic hypogonadism:
Admin. 150 IU 3/w, concom. with hCG, for a min. of 4 months. If no resp. achieved, combin. tmt. for 18 months may be necessary to achieve spermatogen.
See prescr. details.
In adult women:
Anovulat. (incl. polycystic ovarian syndr.) in women unrespon. to clomiphene citrate tmt.
Stimul. of multifollicular dev. in pts. undergoing superovulat. for assisted reprod. techn. (ART) such as in vitro fertil. (IVF), gamete and zygote intra-fallopian transfer (GIFT and ZIFT).
in assoc. with a lutein. horm. (LH) prepar. for the stimul. of follicular dev. in women with sev. LH and FSH defic. In clin. trials these pts. were defined by an endog. serum LH level < 1.2 IU/L.
In adult men:
Stimul. of spermatogen. in men with congen. or acquired hypogonadotrophic hypogonadism with concom. human chorion. gonadotrophin (hCG) therapy.
C/I: hypersens.• tumours of the hypothal. or pituitary gland • ovarian enlargem. or ovar. cyst unrel. to polycystic ovar. dis. and of unknown origin • gynaec. haemorrhages of unkn. origin • ovar., uterine or mammary carc.
must not be used when an effect. resp. cannot be obtained, such as:
• primary ovar. fail. • malform. of sexual organs incompat. with pregn.
• fibroid tumours of the uterus incompat. with pregn. • prim. testic. insuff.
Gonadotropin. Lutropin Alfa 75 IU/ml. VIALS: powd. and solv. for sol. for SC inj.: 1 X 75 IU/ml. 75 IU daily. See lit.
In associat. with follicle stimul. horm. (FSH) for the stimul. of follicul. develop. in adult women with sev. (LH) and FSH deficiency.
C/I: Hypersens.
tumors of the hypothal. and pituitary gland.• ovarian enlargem. or ovar. cyst unrel. to polycystic ovar. dis. and of unkn. orig.• gynaec. haemorrh. of unkn. orig.• ovar., uterine, or mammary carc.
Exist. condit. which makes normal pregn. imposs.
