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  • Follitropin Alfa
    2 Drugs classified under this active ingredient


    All the Active Ingredient Drugs

    Gonal-f
    Merck
    RX
    partial basket chart
    Gonal-f

    Gonadotropin. Follitropin Alfa 600 IU/ml.
    PRE-FILLED PEN: Follitropin alfa 600 IU/
    ml (eq. 44 μg/ml) for S.C. inj. 1 x 300 IU (eq. to 22
    μg)/0.5ml; 1 x 450 IU (eq. to 33 μg)/0.75ml
    1 x 900 IU (eq. to 66 μg)/1.5ml. 
    Women with anovul. (incl. polycystic ovar. syndr.):
    Admin. as a course of daily inject. In menstr. women tmt. should start within the first 7 days of cycle. Common regim. starts at 75 to 150 IU FSH daily and is incr. prefer. by 37.5 or 75 IU at 7- or prefer. 14-days intervals if necessary, to obtain an adeq., but not excess., response. Tmt. should be tailored to patient's respon. by measur. follicle size by US and/or estrog. secret. The max. daily dose is usually not higher than 225 IU FSH. See prescr. details
    Women undergoing ovar. stimul. for mult. follicular develop. prior to IVF or other assisted reprod. techn.:
    Common regim. for superovul. is 150 to 225 IU/d, start on days 2 or 3 of cycle. Tmt. is cont. until adeq. follicular dev. (as by US and/or serum estrogen concentr.) achieved, with dose adjust. to patient's resp., to usually not higher than 450 IU/d. See prescr. details.
    Women with anovul. result. from sev. LH and FSH defic.:
    In LH and FSH defic. women (hypogonadotrophic hypogonadism), the object. of this ther. in assoc. with lutropin alfa is to develop single mature Graafian follicle from which the oocyte will be liberated after administr. of human chorionic gonadotrophin (hCG). This tmt. should be given as a course of daily inject. simultan. with lutropin alfa. Since pts. are amenorrhoeic and have low endogen. estrogen secret., tmt. can commence any time. Recommend. regimen starts at 75 IU of lutropin alfa daily with 75 to 150 IU FSH. Tmt. should be tailored to ptt's respon. by measur. follicle size by US and estrog. respon. See prescr. details.

    Men with hypogonadotrophic hypogonadism:
    Admin. 150 IU 3/w, concom. with hCG, for a min. of 4 months. If no resp. achieved, combin. tmt. for 18 months may be necessary to achieve spermatogen.
    See prescr. details.
    In adult women:
    Anovulat. (incl. polycystic ovarian syndr.) in women unrespon. to clomiphene citrate  tmt.
    Stimul. of multifollicular dev. in pts. undergoing superovulat. for assisted reprod. techn. (ART) such as in vitro fertil. (IVF), gamete and zygote intra-fallopian transfer (GIFT and ZIFT).
    in assoc. with a lutein. horm. (LH) prepar. for the stimul. of follicular dev. in women with sev. LH and FSH defic. In clin. trials these pts. were defined by an endog. serum LH level < 1.2 IU/L.
    In adult men:
    Stimul. of spermatogen. in men with congen. or acquired hypogonadotrophic hypogonadism with concom. human chorion. gonadotrophin (hCG) therapy.
    C/I: hypersens.• tumours of the hypothal. or pituitary gland • ovarian enlargem. or ovar. cyst unrel. to polycystic ovar. dis. and of unknown origin • gynaec. haemorrhages of unkn. origin • ovar., uterine or mammary carc.
    must not be used when an effect. resp. cannot be obtained, such as:
    • primary ovar. fail. • malform. of sexual organs incompat. with pregn.
    • fibroid tumours of the uterus incompat. with pregn. • prim. testic. insuff.

    Pergoveris Pre-Filled Pen
    Merck
    RX
    partial basket chart
    Multiple ingredients
    Pergoveris Pre-Filled Pen

    Gonadotropin. Follitropin Alfa 300 IU / 0.48 ml, Lutropin Alfa 150 IU / 0.48 ml.
    Pre-filled pen 0.48/0.72/1.44 ml .Tmt commences with the recomm. dose of 150 IU r-hFSH/75 IU r-hLH dly. and should be tailor. to the indiv. pt’s resp. as assessed by measure. follicle size by US and oestrogen resp.
    If an FSH dose incr. is deemed appropr., dose adaptat. should preferably be after 7 to 14 day intervals and preferably by 37.5 to 75 IU incr. using a licensed follitropin alfa preparat. It may be accept. to extend the durat. of stimul. in any one cycle to up to 5 weeks.
    When an optimal respon. is obtained, a single inject. of 250 micrograms of r-hCG or 5 000 IU to 10 000 IU hCG should be admin. 24 to 48 hours after the last inject of this drug. The ptt. is recommend. to have coitus on the day of, and on the day follow. hCG admin. Alternat., intrauterine insemin. (IUI) and ART may be perform.
    See lit.
    Stimul. of follicular develop. in adlt women with sev. LH and FSH defic..
    In clinic. trials, these pts were defin. by an endogen. serum LH level < 1.2 IU/L.

    C/I: Hypersens. /tumours of the hypothal. and pituit. gland
    / ovarian enlargem. or ovarian cyst unrel. to polycystic ovarian dis. and of unknown orig. /gynaecol. haemorrhages of unknown orig.
    / ovarian, uterine or mamm. carc. /gynaecol. haemorrhages of unknown orig. / ovarian, uterine or mamm. carc.
    Must not be used when an effect. resp. cannot be obtained, such as:
    • primary ovar. fail. • malform. of sexual organs incompat. with pregn.
    • fibroid tumours of the uterus incompat. with pregn.

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