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  • Direct Thrombin Inhibitor
    1 Drug classified under this drug class


    All the Drug Class Drugs

    Pradaxa
    Boehringer Ingelheim
    RX
    partial basket chart
    Pradaxa

    Direct Thrombin Inhibitor. Dabigatran Etexilate 75, 110, 150 mg.
    CAPS: 10, 30, 60 x75 mg, 110 mg, 150
    mg. Dosage ajust. individ. See lit.
    75 mg –Prim. prevent. of ven.
    thromboembol. events in adult pts. who
    have undergone elect. total hip replacem.
    surgery or total knee replac. surg.
    100 mg- Prim. prevent. of ven.
    thromboembol. events in adult pts. who
    have undergone elect. total hip replacem.
    surgery or total knee replac. surg.
    150mg –Prevent. of stroke and syst. embolism in adult pts. with non-valvular
    atrial fibril. (NVAF).
    Tmt. of DVT and PE, and prevent. of recur.
    DVT and PE in adult.
    C/I: Hypersens., severe renal impair.
    (CrCL < 30 mL/min). Active clin. signif.
    bleed., Lesion, condition, if considered a
    signif. risk factor for major bleed. (includ.
    current or recent gastrointes. ulcer.,
    malig. neoplasms at high risk of bleed.,
    recent brain, spinal injury, recent brain,
    spinal, ophthal. surg., recent intracran.
    haemorr., known or suspected
    oesophageal varices, arteriovenous
    malformations, vasc. aneurysms or
    major intraspinal or intracerebral
    vascular abnormalities), Concom. tmt.
    with any other anticoagulants e.g.
    unfraction. heparin (UFH), low molec.
    weight heparins (enoxaparin, dalteparin
    etc), heparin derivat. (fondaparinux etc),
    oral anticoag.(warfarin, rivaroxaban,
    apixaban etc) except under specific
    circumstan. of switching anticoagulant
    ther. or when UFH is given at doses
    necess. to maintain an open central
    venous or arterial catheter. Hepatic
    impair./ liver dis. expected to have any
    impact on surviv., Concom. tmt. with
    systemic ketoconazole, cyclosporine,
    itraconazole, and dronedarone.,
    Prosthetic heart valves require. anticoag
    tmt.

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