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  • Bile Acid Preparations
    3 Drugs classified under this drug class

    All the Drug Class Drugs

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    Bile Acid Preparations. Cholic Acid 50, 250 mg.
    CAPS.:90. Tmt. of inborn errors of prim. bile acid synthesis is 10-15 mg/kg/d, either as a single dly. dose or in divid. doses, for both adult and paed. pts. The dose should be subseq. titrated to the desired effect but should not exceed a max.  of 15mg/kg/d. Where the dose calcul. is not a multiple of 50, the nearest dose below the max.  of 15mg/kg/d should be select., provided that is suffic. to suppress urin. bile acids. If not, the next higher dose should be select. Pts. with concom. familial hypertriglyceridemia is 11 to 17 mg/kg once dly. or in two divid. doses and is adjust. based on clin. response.
    Tmt. of  infants, child., adolesc.  aged 1m.-18 yrs. and adults of inborn errors in prim. bile acid synthesis due to Sterol 27-hydroxylase (presenting as cerebrotendinous xanthomatosis, CTX) defic., 2- (or α-) methylacyl-coa racemase (AMACR) defic., Cholesterol 7α -hydroxylase (CYP7A1) defici.,  3β-hydroxy-5-C27-steroid oxidoreductase defic.,(also known as 3β-hydroxy-5-C27-steroid dehydrogenase/isomerase or 3β-HSD or HSD3β7.
    C/I: Hypersens. Concom. use with phenobarbital.

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    Bile Acid Preparations. Ursodeoxycholic Acid 250mg, 500mg.
    CAPS: 100 x 250 mg. 2-6 caps dly (10-15
    mg/kg), depend. on wt. and dis. course.
    Swallow whole with little liq. aft. meals
    and before bedt.
    F.C.TABS: 50 x 500 mg. Sympt. tmt. of
    PBC: The dly. dose depends on bdy. wt
    and ranges from 1½ to 3½ tabs. (14 ± 2
    mg of Ursodeoxycholic acid per kg of
    bdy. wt). Swallow whole with little liq. aft. meals and before bedt. For the first 3 mths. of tmt., should be taken divided per day. When the liver funct. paramet.
    improve, the dly. dose may be taken
    once dly. in the eve, must be taken
    Chron. liver dis: Prim. biliary cirrhosis,
    prim. scleros. cholangit.
    Ursofalk 500: sympt. tmt. of prim. biliary
    cirrhosis in pts. without decompensated
    hep. cirrhosis.
    C/I: Hypersens., Acute inflamm. of
    gallbladder or biliary tract., Occlus. of
    the biliary tract, Freq. episodes of biliary
    colic., Radio-opaque calcified gallstones,
    Impair. contract. of the gallbladder.
    pregn., lact.

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    Bile Acid Preparations. Ursodeoxycholic Acid 100 mg, 300 mg.
    TABS: 30 x 300 mg; 60, 100 x 100 mg. Chron.
    liver dis: Adults and child: 8-10 mg/kg
    bdy. wt. div. into 1 or 2 doses. Larger
    doses may be admin. accord. to age
    and severity. Child: Cholestat. liver dis.,
    hepat. bilary atresia: Total dly. dose:
    10-18 mg/kg bdy. wt. Gallstones:
    Adults and child over 6 yrs: 8-10 mg/
    kg bdy. wt. div. into 2-3 doses dly. aft.
    Gallstones (with funct. gall bladder),
    chron. liver dis.