All the Drug Class Drugs
Antimetabolite (antifolate). Pemetrexed 100 mg, 500 mg. VIAL: 1X 100 mg, 500 mg. Comb. use
with cisplatin: 500 mg/m2 I.V. over 10
mins. on day 1 of each 21-day cycle.
Recommend. dose cisplatin: 75 mg/m2
I.V. over 2 hrs. begin. 30 mins. aft. end
of Alimta admin.
Monother: 500 mg/m2 IV over 10 mins.
on the 1 day of each 21-day cycle. See
lit.
In comb. with cisplatin for tmt.: malignant
pleural mesothelioma whose dis.
unresectable or otherwise not candidates
for curative surg.; first line tmt. locally
advanced/ metastat. non-small cell
lungcancer other than predom. Squamous
cell histology. As monother: in local.
advanced/ metastat. non-small cell lung
cancer other than predom. squamous cell
histology histology in patients whose dis.
has not progressed immediately following
platinum-based chemotherapy; second
line tmt. locally advanced/metastat.
nonsmall cell lung cancer, other than
predom. squamous cell histology.
C/I: Hypersens., lact., concom. yellow
fever vaccine.
Antimetabolite (antifolate). Pemetrexed 100, 500, 1000 mg. VIAL(Pwdr.for concent. for sol. for infus.):1. Comb. with cisplatin: 500 mg/m2 of bdy. surface area (BSA) admin. as an IV infus. over 10 min. on the 1st day of each 21-day cycle. The recomm. dose of cisplatin is 75 mg/m2 BSA infused over 2 hrs. approx. 30 min. after complet. of the pemetrexed infus. on the 1st day of each 21-day cycle. Pts. must receive adequate anti-emetic tmt. and appropr. hydration prior to and/or after receiv. cisplatin. Pemetrexed as single agent: In pts. treat. for NSCLC after prior chemother., the recomm. dose of pemetrexed is 500 mg/m2 BSA admin. as an IV infus. over 10 min. on the 1st day of each 21-d. cycle.
For pre-medic. regimen, pt. monitor., & dose ajust.: See lit.
In comb. with cisplatin: for the tmt. of pts. with malig. pleural mesothelioma whose dis. is unresect. or who are otherwise not candidates for curatible surg.
In comb. with cisplatin: 1st line tmt. of pts. with local. advanc. or metastat. non-small cell lung canc. other than predom. squamous cell histology.
As monother. for the 2nd line tmt. of pts. with local. advanc. or metastat. non-small cell lung canc. other than predominant. squamous cell histology.
As monother. for the maintenan. tmt. of locally advance. or metastat. non-small cell lung canc. other than predominant. squamous cell histology in pts. whose dis. has not progress. immediat. follow. platinum-based chemother.
C/I: Hypersens.
Lact.
Concomit. use yellow fever vaccine.