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  • Antimetabolite (antifolate)
    2 Drugs classified under this drug class


    All the Drug Class Drugs

    Alimta
    Eli Lilly
    RX
    partial basket chart
    Alimta

    Antimetabolite (antifolate). Pemetrexed 100 mg, 500 mg.
    VIAL: 1X 100 mg, 500 mg. Comb. use
    with cisplatin: 500 mg/m2 I.V. over 10
    mins. on day 1 of each 21-day cycle.
    Recommend. dose cisplatin: 75 mg/m2
    I.V. over 2 hrs. begin. 30 mins. aft. end
    of Alimta admin.
    Monother: 500 mg/m2 IV over 10 mins.
    on the 1 day of each 21-day cycle. See
    lit.
    In comb. with cisplatin for tmt.: malignant
    pleural mesothelioma whose dis.
    unresectable or otherwise not candidates
    for curative surg.; first line tmt. locally
    advanced/ metastat. non-small cell
    lungcancer other than predom. Squamous
    cell histology. As monother: in local.
    advanced/ metastat. non-small cell lung
    cancer other than predom. squamous cell
    histology histology in patients whose dis.
    has not progressed immediately following
    platinum-based chemotherapy; second
    line tmt. locally advanced/metastat.
    nonsmall cell lung cancer, other than
    predom. squamous cell histology.
    C/I: Hypersens., lact., concom. yellow
    fever vaccine.

    Pemetrexed Taro
    Taro International Ltd
    RX
    full basket chart
    Pemetrexed Taro

    Antimetabolite (antifolate). Pemetrexed 100, 500, 1000 mg.
    VIAL(Pwdr.for concent. for sol. for infus.):1. Comb. with cisplatin: 500 mg/m2 of bdy. surface area (BSA) admin. as an IV infus. over 10 min. on the 1st day of each 21-day cycle. The recomm. dose of cisplatin is 75 mg/m2 BSA infused over 2  hrs. approx. 30 min. after complet. of the pemetrexed infus. on the 1st  day of each 21-day cycle. Pts. must receive adequate anti-emetic tmt. and appropr. hydration prior to and/or after receiv. cisplatin. Pemetrexed as single agent: In pts. treat. for NSCLC after prior chemother., the recomm. dose of pemetrexed is 500 mg/m2 BSA admin. as an IV infus.  over 10 min. on the 1st  day of each 21-d. cycle.
    For pre-medic. regimen, pt. monitor., & dose ajust.: See lit.
    In comb. with cisplatin: for the tmt. of pts. with malig.  pleural mesothelioma whose dis. is unresect. or who are otherwise not candidates for curatible surg.
     In comb. with cisplatin: 1st  line tmt. of pts. with local. advanc. or metastat. non-small cell lung canc. other than predom. squamous cell histology.
    As monother. for the 2nd line tmt. of pts. with local. advanc.  or metastat. non-small cell lung canc. other than predominant.  squamous cell histology.
    As monother.  for the maintenan.  tmt. of locally advance. or metastat. non-small cell lung canc. other than predominant. squamous cell histology in pts. whose dis. has not progress. immediat.  follow. platinum-based chemother.

    C/I
    : Hypersens.
    Lact.
    Concomit. use yellow fever vaccine.

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