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  • 1st Generation Cephalosporins
    1 Drug classified under this drug class

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    1st Generation Cephalosporins. Cefazolin as sodium 1000 mg/vial.
    VIAL (pwdr. for sol. for inj.): 10×10ml. The dosage depends on pathogen sensitiv. and the severity of the dis. See lit.
    Tmt. of serious infect. caused by suscept. org. & also perioperat. for prophylaxis.
    Tmt. Respir. tract infec. due to streptococcus pn.(formerly diplococcus p.) klebsiella species haemophilus influenzae staphylococcus a. (penicillin-sensit. & penicillin-resist.) and group A B – hemolyt. streptococci. Cefazolin is effect. in the eradic. of streptococci from the nasopharynx. However data establish. the efficacy of cefazolin in the subseq. prevent. of rheumat. fever are not available at present. UTI infec.: due to escherichia coli klebsiella species proteus mirabilis and some strains of Enterobacter & enterococci. Skin & skin struct.: -hemolytic beta Infec. due to Staphylococcus a. (penicillin-sensit. & penicillin-resist.) group A streptococci & other strains of streptococci.
    Biliary tract infec. due to escherichia coli various strains of streptococci pr. mirabilis klebsiella species and staphylococcus a. Bone & joint infec. due to staphylococcus a.
    Genit. infec. (i.e. prostatitis epididymitis) due to escherichia coli proteus mirabilis klebsiella species and some strains of enterococci. Septicemia due to streptococcus pneumoniae (formerly diplococcus pneum.) staphylococcus aureus (penicillin-sensit.  and penicillin-resist.) proteus mirabilis escherichia coli and klebsiella species.
    Endocardit. caused by staphylococcus aureus: (penicillin-sensit.&penicillin-resis.) &gr. A beta-hemolytic streptococci. Appropriate culture and susceptib. studies should be performed to determine the susceptib. of the causative org. to cefazolin.
    Perioperat. prophylaxis: The prophylactic admin. of cefazolin peri-operat. (preoperat. intra-operat.& postoperat.) may reduce the incidence of certain postoperat. infec. in pts. undergoing surgical proced. (e.g. hysterectomy GI surg. & transurethral prostatectomy) that are classified as contamin. or potent. contamin. The perioperat. use of cefazolin may also be effective in surg. pts. in whom infec. at the operat. site would present a serious risk (e.g. open-heart surg. & prosthetic arthroplasty).
    C/I: Known hypersens. to cefazolin or other cephalosporins. Pts. who have prev. shown immed. and/or severe hypersens. reactions to penicillin or to any other beta-lactam antibiot.