All the Active Ingredient Drugs
EGFR Inhibitor, Kinase Inhibitor. Vandetanib 100 mg. FC TABS: 30 x 100mg. Recom.
dose 300mg 1x dly. Pts. must be given
patient alert card and be informed of
risks Assess QTc interval prior to init.
tmt. Can reduce dosage if necess.
See lit.
Tmt. aggressive and sympt. medullary
thyroid cancer (MTC) in pts. with
unresectable locally advanced or
metastatic dis. Pts.in whom Rearranged
during Transfection (RET) mutation is not
known or is neg., a possible lower benefit
should be taken into account. See lit.
C/I: Hypersens. to active subst. or excip;
congenital long QTc syndrome; pts. with
QTc interval > 480msec.; concomit. use
of arsenic, cisapride,erythromycin, iv.
toremifene, mizolastine moxifloxacin,
class Ia and III antiarrhythmics. See lit.