All the Active Ingredient Drugs
Janus Kinase Inhibitor (JAKs). Upadacitinib 15 mg, 30 mg, 45 mg. PR Tabs 30/90 X 15 /30/45 mg
Rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: adults 15 mg /d. Juvenile psoriatic arthritis and Polyarticular Juvenile Idiopathic Arthritis:15 mg/d. Atopic dermatitis: adults 15 mg /d/ or 30 mg once/d based on indiv. patient presentation. Adolesc. (aged 12-17) : 15 mg once/d for adolesc. weighing at least 30 kg. UC and Crohn dis.: induction: 45 mg/d for 8 w /12 w, maintenance: 15 mg/d or 30 mg/d. See full prescription info.
Rheumatoid arthritis : tmt. of moder. to sev. active rheumatoid arthritis in adults who have responded inadeq. to, or who are intoerl. to one or more disease-modifying anti-rheumatic drugs (DMARDs). This drug may be used as monother. or in combin. with methotrexate (MTX). Psoriatic arthritis tmt. of active psoriatic arthritis in adults who have responded inadeq. to, or who are intoler. to one or more DMARDs. May be used as monother. or in combin. with MTX. Non-radiographic axial spondyloarthritis (nr-axSpA): tmt. of active non-radiographic axial spondyloarthritis in adults with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or MRI, who have responded inadeq. to NSAIDs. Ankylosing spondylitis (AS, radiographic axial spondyloarthritis): tmt. of active ankylosing spondylitis in adults who have responded inadeq. to conventional ther.
Juvenile psoriatic arthritis and Polyarticular Juvenile Idiopathic Arthritis: treatment of pts. 2 years of age and older who had an inadeq. resp. or intoler. to one or more TNF blockers.
Atopic dermatitis: tmt. of moder. to sev. atopic dermatitis in adults and adolesc. 12 years and older who are candidates for syst. ther. Ulcerative colitis: tmt. of adults with mod. to sev. active ulcerative colitis who had an inadeq. resp., lost resp. or were intol. to either conventional ther. or a biologic agent. Crohn’s disease: tmt. of adults with moder. to sev. active Crohn’s disease who had an inadeq. resp., lost resp. or were intol. to either conventional ther. or a biologic agent.
C/I: Hypersens. · Active tuberculosis (TB) or active serious infect. · Severe hepatic impairment · Pregn.
