Lutropin Alfa

2 Drugs classified under this active ingredient

Gonadotropin. Lutropin Alfa 75 IU/ml.
VIALS: powd. and solv. for sol. for SC inj.: 1 X 75 IU/ml. 75 IU daily. See lit.
In associat. with follicle stimul. horm. (FSH) for the stimul. of follicul. develop. in adult women with sev. (LH) and FSH deficiency.
C/I: Hypersens.
tumors of the hypothal. and pituitary gland.• ovarian enlargem. or ovar. cyst unrel. to polycystic ovar. dis. and of unkn. orig.• gynaec. haemorrh. of unkn. orig.• ovar., uterine, or mammary carc.
Exist. condit. which makes normal pregn. imposs.

Gonadotropin. Follitropin Alfa 300 IU / 0.48 ml, Lutropin Alfa 150 IU / 0.48 ml.
Pre-filled pen 0.48/0.72/1.44 ml .Tmt commences with the recomm. dose of 150 IU r-hFSH/75 IU r-hLH dly. and should be tailor. to the indiv. pt’s resp. as assessed by measure. follicle size by US and oestrogen resp.
If an FSH dose incr. is deemed appropr., dose adaptat. should preferably be after 7 to 14 day intervals and preferably by 37.5 to 75 IU incr. using a licensed follitropin alfa preparat. It may be accept. to extend the durat. of stimul. in any one cycle to up to 5 weeks.
When an optimal respon. is obtained, a single inject. of 250 micrograms of r-hCG or 5 000 IU to 10 000 IU hCG should be admin. 24 to 48 hours after the last inject of this drug. The ptt. is recommend. to have coitus on the day of, and on the day follow. hCG admin. Alternat., intrauterine insemin. (IUI) and ART may be perform. See lit.
Stimul. of follicular develop. in adlt women with sev. LH and FSH defic..
In clinic. trials, these pts were defin. by an endogen. serum LH level < 1.2 IU/L.
C/I: Hypersens. /tumours of the hypothal. and pituit. gland
/ ovarian enlargem. or ovarian cyst unrel. to polycystic ovarian dis. and of unknown orig. /gynaecol. haemorrhages of unknown orig.
/ ovarian, uterine or mamm. carc. /gynaecol. haemorrhages of unknown orig. / ovarian, uterine or mamm. carc.
Must not be used when an effect. resp. cannot be obtained, such as:
• primary ovar. fail. • malform. of sexual organs incompat. with pregn.
• fibroid tumours of the uterus incompat. with pregn.