Levetiracetam

5 Drugs classified under this active ingredient

Anticonvulsant. Levetiracetam 100 mg/ml.
ORAL SOLN: 300 ml x 100 mg/ml. Adult,
child & adolesc. 12-17 yrs, wt. 50 kg or
more: Initial: 500 mg 2 x dly on 1st day
of tmt. Depend. on clin. response/
tolerabil. can incr. dly dose up to 1,500
mg 2 x dly. Dose changes can be made
in 500 mg increments/decrements 2 x
dly every 2-4 wks. Child 4-17 yrs wt.
less than 50 kg: Initial 10 mg/kg body
wt 2 x dly. Depend. on clin./tolerabil,.
incr. up to 30 mg/kg bdy wt. 2 x dly
every 2 wks. Dose changes not to
exceed increments/decrements of 10
mg/kg bdy wt. 2 x dly every 2 wks. Use
lowest effect. dose. Inf./child under 4
yrs: Not recommend. Elderly: Adjust if
renal funct. compromised. Renal
impair: Adjust individ. accord. to ren.
funct. Severe hepat. impair: Creatinine
clear. may underest. ren. insuffic; 50%
reduct. dly maint. dose is recommend.
at creatinine clear. of <70 ml/min.
Adjunct. ther. tmt partial onset seiz. with/
without second. generaliz. pts with
epilepsy.
C/I: Hypersens.

Anticonvulsant. Levetiracetam 250, 500, 1000 mg.
F.C. TABS: 60 x 250 mg, 500 mg, 1,000
mg. Adult, child & adolesc. 12-17 yrs, wt. 50 kg or more: Initial: 500 mg 2 x dly on 1st day of tmt. Depend. on clin. response/
tolerabil. can incr. dly dose up to 1,500
mg 2 x dly. Dose changes can be made
in 500 mg increments/decrements 2 x
dly every 2-4 wks. Child 4-17 yrs wt.
less than 50 kg: Initial 10 mg/kg body
wt 2 x dly. Depend. on clin./tolerabil,.
incr. up to 30 mg/kg bdy wt. 2 x dly
every 2 wks. Dose changes not to
exceed increments/decrements of 10
mg/kg bdy wt. 2 x dly every 2 wks. Use
lowest effect. dose. Inf./child under 4
yrs: Not recommend. Elderly: Adjust if
renal funct. compromised. Renal
impair: Adjust individ. accord. to ren.
funct. Severe hepat. impair: Creatinine
clear. may underest. ren. insuffic; 50%
reduct. dly maint. dose is recommend.
at creatinine clear. of <70 ml/min.
Adjunct. ther. tmt partial onset seiz. with/
without second. generaliz. pts with
epilepsy.
C/I: Hypersens.

Anticonvulsant. Levetiracetam 250, 500, 750, 1000 mg.
Tabs. 60 X 250/500/750/1000 mg
 Monother.: Adult. & adolesc.from 16 yrs. of age:starting recommen. dose is 250 mg ×2/d which should be incr. to an init. therap. dose of 500 mg ×2/d after two wks. The dose can be further incr. by 250 mg ×2/d every two wks. depend. upon clinical response. Max. dose is 1500 mg ×2/d.
Add-on ther.: Adult. (≥18 yrs.) and adolesc. (12 - 17 yrs.) weigh.≥50 kg: The init. therap. dose is 500 mg ×2/d. This dose can be init. on the 1^st day of tmt. Depend. upon the clinic. response and tolerab., dly. dose can be incr. up to 1,500×2/d. Dose changes can be made in 500 mg ×2/d incr. or decr.every 2-4 wks.
Childr.  aged 6 - 11 yrs. and adolesc (12 - 17 yrs.) weigh. <50 kg:  The init. therap. dose is 10 mg/kg×2/d. Depend. upon clinic. response and tolerab., dose can be incr. up to 30 mg/kg ×2/d . Dose changes should not exceed incr. or decr. of 10 mg/kg ×2/d  every 2 wks. The lowest effect. dose should be used.
Add-on therapy for childr. (4 to 11 years) and adolesc. (12 to 17 years) weighing less than 50 kg :oral sol. is the preferred formul. for use in childr. under the age of 6.
For childr. 6 years and above, the oral sol. should be used for doses under 250 mg, for doses not multiple of 250 mg, when dosing recomm. is not achievable by taking multiple tabs. and for pts. unable to swallow tabs. The lowest effective dose should be used. Start. dose for a child or adolesc. of 25 kg should be 250 mg x2/d with a max. dose of 750 mg X2/d.
Dose in childr. 50 kg or greater is the same as in adults.
The init. therap. dose is 10 mg/kg X2/d.
Depending upon clinical resp. and tolerab., dose can be incr. up to 30 mg/kg X2/d. Dose changes should not exceed incr. or decr. of 10 mg/kg X2/d every two weeks. The lowest effective dose should be used. See lit
As monother. in the tmt. of partial onset seizures. with/without second. generalisat. in pts. from 16 yrs  of age with newly diagnos. epilepsy.
As adjunct. ther. in the tmt. of partial onset seizures with/without second. generalisat. in adult. & childr. from 4 yrs. of age with epilepsy.
In the tmt. of myoclon. seizures in adult. & adolesc. from 12 yrs. of age with Juvenile Myoclonic Epilepsy.
In the tmt. of prim. generalised. tonic-clonic seizures in adults & adolesc. from 12 yrs. of age with Idiopathic Generalised Epilepsy.
C/I: Hypersens. to levetiracetam or other pyrrolidone derivat.

Anticonvulsant. Levetiracetam 250 mg, 500 mg, 1,000 mg.
TABS: 10, 60 x 250 mg, 500 mg, 1,000
mg. Adult, child & adolesc. 12-17 yrs,
wt. 50 kg or more: Initial: 500 mg 2 x
dly on 1st day of tmt. Depend. on clin.
response/tolerabil. can incr. dly dose
up to 1,500 mg 2 x dly. Dose changes
can be made in 500 mg increments/
decrements 2 x dly every 2-4 wks. Child
4-17 yrs wt. less than 50 kg: Initial 10
mg/kg body wt 2 x dly. Depend. on
clin./tolerabil,. incr. up to 30 mg/kg bdy
wt. 2 x dly every 2 wks. Dose changes
not to exceed increments/decrements
of 10 mg/kg bdy wt. 2 x dly every 2
wks. Use lowest effect. dose. Inf./child
under 4 yrs: Not recommend. Elderly:
Adjust if renal funct. compromised.
Renal impair: Adjust individ. accord. to
ren. funct. Severe hepat. impair:
Creatinine clear. may underest. ren.
insuffic; 50% reduct. dly maint. dose is
recommend. at creatinine clear. of <70
ml/min.
Adjuv. ther. partial onset seizures with/
out second. generalizat. in adults, child
from 4 yrs with epilepsy. Adjunct. ther.
myoclon. seizures in adults and adolesc.
from 12 yrs of age with juvenile
myoclonic epilepsy. Monother. partial
onset seizures with/out second.
generalizat. in pts. from 16 yrs of age
with newly diagn. epilepsy. Tmt. primary
general. tonic-clonic seizures in adults
and adolesc. from 12 yrs with idiopath.
general. epilepsy.
C/I: Hypersens.

Anticonvulsant. Levetiracetam 100 mg/ml.
SOL.: 300 ml. Dosage must be ajust.
individ. for each pt. See lit.
Monother. in the tmt. of part. onset seiz.
with or without 2nd generalis. in pts. from
16 yrs. of age with newly diagnosed
epilepsy. Adjunct. ther.: Tmt. of partial
onset seiz. with/ without 2nd generalis. in
adult./child. from 4 yrs. of age with
epilepsy. Tmt. of myoclon. seiz. in adult./
adolesc. from 12 yrs. of age with juvenile
myoclon. epilepsy. Tmt. of prim. generalis.
tonic-clonic seiz. in adult./adolesc. from
12 yrs. of age with idiop. generalis.
epilepsy.
C/I: Hypersens. Known, rare, hereditary
intoler. to fructose.