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  • Alteplase
    1 Drug classified under this active ingredient

    All the Active Ingredient Drugs

    Boehringer Ingelheim
    not in the basket chart

    Thrombolytic Agent. Alteplase 20 mg/vial, 50 mg/Vial.
    VIAL. (pwdr.+ solvent for sol. for inject./
    infus.): 1 + 1 vial of solvent. Dosage
    must be ajust. individ according to pt.
    med. cond.
    Acute MI: In adults for the lysis of thrombi
    obstruct. coron. arteries, the reduction of
    infarct size, the improve. of ventr. func., the
    reduction of the incidence of congest.
    heart fail., reduct. of mortality assoc. with
    AMI. Tmt. should be initiated as soon as
    possible after the onset of AMI sympt.
    Acute Massive Pulmon. embol. with
    hemodynamic deprivation.: Management
    of acute massive pulmonary embolism
    (PE) in adults: For the lysis of acute pulm.
    emboli, defined as obstruct. of blood flow
    to a lobe or multiple segments of the lung,
    For the lysis of pulmon. emboli
    accompanied by unstable hemodynamics
    e.g. fail.to maintain blood pressure
    without supportive measures.
    The diagnosis should be confirmed by
    objective means, such as pulmon.
    angiography or noninvasive procedures
    such as lung scanning.For fibrinolytic
    treatment of acute ischaemic stroke Tmt.
    must be started as early as possible within
    4.5 hrs. after onset of stroke sympt.and
    after exclusion of intracr. haemorrhage by
    appropriate imaging techniques (e.g.
    cranial CT or other diag. imaging method
    sensitive for the presence of
    haemorrhage). The tmt. effect is timedependent;
    therefore earlier tmt. incr. the
    probability of a favourable outcome.
    C/I: Hypersens. High risk cases of
    haemorrhage such e.g.: Signific. bleed.
    disor. at present or within the past 6
    mnths. Known haemorrhage.diathesis.
    Pts. receiving effective oral anticoag.
    tmt., e.g. warfarin sodium (INR>1.3). Manifest or recent severe or dangerous bleed. Known hist. of or suspected intracran.
    haemorrhage. Suspected subarachnoid
    haemorrhage/condition after subarachnoid haemorrhage from aneurysm. Any history of CNS damage (i.e. neoplasm, aneurysm, intracran./spinal surg.). Recent (less than 10 days) traumatic external heart massage,
    obstetrical delivery, recent puncture of a
    non-compressible blood-vessel (e.g.
    subclavian or jugular vein puncture).
    Severe uncontrol.arterial hypertens.
    Bact. endocarditis, pericarditis. Acute
    pancreatitis. Documented ulcerative GI
    dis. during the last 3 mnths., oesophageal varices, arterial-aneurysm, arterial/venous malformations.
    Neoplasm with incr. bleed.risk. Severe liver dis., includ. hep. fail., cirrhosis, portal hypertension (oesophageal varices) and active hepatitis. Major surg. or signific. trauma in past 3 mnths.
    Addit. contraind. in acute massive pulmonary embolism, MI, acute ischaemic stroke: see lit.
    Acute ischaemic stroke in child. under 16 yrs old.