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  • Albutrepenonacog Alfa
    1 Drug classified under this active ingredient

    All the Active Ingredient Drugs

    not in the basket chart

    Antihemophilic Agent. Albutrepenonacog Alfa 250, 500, 1000, 2000 IU.
    VIAL (pwdr. and solvent for sol. for inj.): 1+1. 1 IU of factor IX activ. is equiv. to that quant. of factor IX in 1 ml of normal human plasma.
    On demand tmt.: The calculat. of the requir. dose of factor IX is based on the empiric. finding that 1 IU factor IX per kg bdy. wt. is expected to incr. the circulating level of factor IX by an average of 1.3 IU/dl (1.3% of normal) in pts. ≥ 12 yrs. of age and by 1.0 IU/dl (1.0 % of normal) in pts. < 12 yrs. of age. The required dose is determ. using the follow. formulae:
    Required dose (IU) = bdy. wt.(kg) x desired factor IX rise (% of normal or IU/dl) x {reciprocal of observed recovery (IU/kg per IU/dl)}
    Expected factor IX rise (IU/dl or % of normal) = Dose (IU) x Recovery (IU/dl per IU/kg)/body weight (kg).
    The amount to be admin. and the frequen. of admin. should always be oriented to the clinical effectiveness in the individ. case.
    Pts.<12 yrs. of age: For an incremental recovery of 1 IU/dl per 1 IU/kg, the dose is calculated as follows: Dose (IU) = bdy. wt (kg) x desired factor IX incr. (IU/dl) x 1 dl/kg. See Lit.
    Tmt. and prophylaxis of bleed. in pts. with haemophilia B (congenit. factor IX defic.).
    C/I: Hypersens. to the active subst. (recomb. fusion protein linking coagulat. factor IX with albumin (rIX-FP). Known allergic reaction to hamster protein.