Ventolin Respirator Solution

/ GSK

Ventolin Respirator Solution is for inhalation use only, to be breathed in through the mouth, under the direction of a physician, using a suitable nebuliser. The solution should not be injected or swallowed. Ventolin  Respirator Solution may be administered intermittently or continuously. Salbutamol has a duration of action of 4 to 6 hours in most patients.
Intermittent administration
Adults: Ventolin Respirator solution 0.5ml (2.5mg of salbutamol) should be diluted to a final volume of 2ml with sterile normal saline. This may be increased to 1ml (5mg of salbutamol) diluted to a final volume of 2.5ml. The
resulting solution is inhaled from a suitably driven nebuliser until aerosol
generation ceases. Using a correctly matched nebuliser and driving source this
should take about ten minutes.
Ventolin Respirator Solution may be used undiluted for intermittent administration. For this, 2ml of Ventolin Respirator Solution (10mg of salbutamol) is placed in the nebuliser and the patient allowed to inhale the
nebulised solution until bronchodilation is achieved. This usually takes 3 – 5
minutes. Some adult patients may require higher doses of salbutamol up to
10mg, in which case nebulisation of the undiluted solution may continue until
aerosol generation ceases. Intermittent treatment may be repeated up to four
times daily.
Paediatric Population: The same mode of administration for intermittent administration is also applicable to children. The minimum starting dosage for children under the age of 12 years is 0.5ml (2.5mg of salbutamol) diluted to 2 to 2.5ml with sterile normal saline. Some children (over the age of 18 months) may, however, require higher doses of salbutamol up to 5mg. Intermittent treatment may be repeated up to four times daily.
Children aged 12 years and over: Dose as per adult population.
In infants under 18 months the clinical efficacy of nebulised salbutamol is
uncertain. As transient hypoxaemia may occur supplemental oxygen therapy
should be considered.
Continuous administration
Ventolin Respirator Solution is diluted with sterile normal saline to contain
50-100 micrograms of salbutamol per ml, (1-2ml solution made up to 100ml
with diluent). The diluted solution is administered as an aerosol by a suitably
driven nebuliser. The usual rate of administration is 1-2mg per hour.

Severe acute asthma (status asthmaticus) and other forms of bronchospasm.

History of hypersensitivity to any component.

Patient response should be monitored clinically and by lung function tests. Patients receiving treatment at home should be warned that if either the usual relief is diminished or the usual duration of action reduced, they should not increase the dose or its frequency of administration, but should seek medical advice. Patients known to have received large doses of other sympathomimetic drugs. Patients with thyrotoxicosis. A combination of nebulized salbutamol with nebulized anticholinergics should be used cautiously. Pregnancy and lactation: Should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. Use in nursing mothers is not recommended unless the expected benefits outweigh any potential risk.

Fine tremor of skeletal muscle, usually the hands. Feelings of tension, headaches. Rare reports of muscle cramps. Hypersensitivity reactions, including angioedema and urticaria, bronchospasm, hypotension. Cardiac arrhythmias.