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  • Pyridostigmine
    / Rafa


    Active Ingredient
    Pyridostigmine (as Bromide) 30 mg, 60 mg

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Tablets

    21 X 30 mg

    full basket chart 8299 16620

    Tablets

    30 X 60 mg

    full basket chart 26166 16834

    Related information


    Dosage

    The medicine takes 30-60 minutes until it begins to take effect from the moment you take the determined dose. The effect lasts between 4 to 6 hours. Therefore, consult with your doctor about the optimal times for taking the medicine, so that it will have an effect when there is need for the muscles to
    work, for example, 30-60 minutes before a meal.


    Indications

    Myasthenia gravis.


    Contra-Indications

    Hypersensitivity to anticholinesterases and bromide. Mechanical urinary or intestinal obstruction.


    Special Precautions

    Bronchial asthma, cardiac dysrhythmias, epilepsy, recent coronary occlusion, vagotonia, hyperthyroidism, peptic ulcer, Parkinson’s disease, transient bradycardia. Pregnancy and lactation: Safety of use has not been established. Use only when clearly needed and when the potential benefits outweigh the unknown potential hazards to the fetus. The potentially serious adverse reactions in the nursing infants should be weighed against the importance of the drug to the mother.


    Side Effects

    The side effects of pyridostigmine bromide are most commonly related to overdose and generally are of two varieties.
    Muscarinic: nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis.
    Nicotinic: muscle cramps, fasciculation and weakness. Other possible side effects are diplopia, conjunctival hyperemia, dyspnea, headache, laryngospasm, bronchospams, AV block, syncope, arthralgia, urinary frequency and incontinence, and alopecia.


    Drug interactions

    Aminoglycoside antibiotics, anticholinesterase drugs. Routing administration of atropine or belladonna deratives. Methocarbamol, mecamylamide, magnesium, neuromuscular blocking agents, malathion, guanethidine, anti-glaucoma agents containing phospholine iodide, anti-arrhythmic drugs, some general and local anesthetics.
    See prescribing information for full details.


    Manufacturer
    Rafa Laboratories Ltd.
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