Pyridostigmine

/ Rafa

The medicine takes 30-60 minutes until it begins to take effect from the moment you take the determined dose. The effect lasts between 4 to 6 hours. Therefore, consult with your doctor about the optimal times for taking the medicine, so that it will have an effect when there is need for the muscles to
work, for example, 30-60 minutes before a meal.

Myasthenia gravis.

Hypersensitivity to anticholinesterases and bromide. Mechanical urinary or intestinal obstruction.

Bronchial asthma, cardiac dysrhythmias, epilepsy, recent coronary occlusion, vagotonia, hyperthyroidism, peptic ulcer, Parkinson’s disease, transient bradycardia. Pregnancy and lactation: Safety of use has not been established. Use only when clearly needed and when the potential benefits outweigh the unknown potential hazards to the fetus. The potentially serious adverse reactions in the nursing infants should be weighed against the importance of the drug to the mother.

The side effects of pyridostigmine bromide are most commonly related to overdose and generally are of two varieties.
Muscarinic: nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis.
Nicotinic: muscle cramps, fasciculation and weakness. Other possible side effects are diplopia, conjunctival hyperemia, dyspnea, headache, laryngospasm, bronchospams, AV block, syncope, arthralgia, urinary frequency and incontinence, and alopecia.

Aminoglycoside antibiotics, anticholinesterase drugs. Routing administration of atropine or belladonna deratives. Methocarbamol, mecamylamide, magnesium, neuromuscular blocking agents, malathion, guanethidine, anti-glaucoma agents containing phospholine iodide, anti-arrhythmic drugs, some general and local anesthetics.
See prescribing information for full details.