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  • Dibenyline
    / Rafa


    Active Ingredient

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Capsules

    30 X 10 mg

    partial basket chart 26642 4109

    Related information


    Dosage

    Adults: The usual starting dose is 10 mg daily. This may be increased by 10 mg daily until control of hypertensive episodes is achieved, or postural hypotension occurs. Usually the dosage required is 1-2 mg/kg body weight split into 2 doses. Concomitant beta-adrenergic blockade may be necessary to control tachycardia and arrythmias notably when tumours are secreting an appreciable amount of adrenaline as well as noradrenaline.
    Elderly: Use with caution, 10 mg daily dose should be sufficient.
    Children: There is little experience in children but, doses of 1 to 2 mg/kg daily have been used successfully.


    Indications

    Pheochromocytoma, urinary retention, Benign Prostatic Hypertrophy (BPH) and neurogenic bladder.


    Contra-Indications

    Phenoxybenzamine should not be used in patients who have had a cerebrovascular accident; or in the recovery period (usually 3-4 weeks) after acute myocardial infarction.


    Special Precautions

    Phenoxybenzamine should be used with great caution in patients in whom a fall in blood pressure and/or tachycardia may be undesirable, such as the elderly or those with severe heart disease, congestive heart failure, cerebrovascular disease or renal damage. The mode of action should be borne in mind, if used concurrently with α- sympatho-mimetics or myocardial depressants. Phenoxybenzamine is carcinogenic in the rat and has shown mutagenic activity in the bacterial Ames test and mouse lymphoma assay. It should only be used after very careful consideration of the risks, in patients in whom alternative treatment is inappropriate.


    Side Effects

    Side effects are generally mild and transient, but may include postural hypotension with dizziness and compensatory tachycardia, nasal congestion, inhibition of ejaculation, miosis and lassitude. Gastrointestinal upset has also been reported.


    Drug interactions

    See under Special Precautions and Warnings.


    Pregnancy and Lactation

    There is little evidence of safety of Dibenyline in pregnancy and it should not be used in pregnancy or during breastfeeding unless essential.


    Overdose

    The main effect of overdose is profound hypotension, which may last several hours, tachycardia and collapse. Treatment consists of the induction of vomiting and/or gastric lavage together with appropriate symptomatic and supportive measures. Hypotension should be treated with plasma expanders and placing the patient in the “head down” position. Noradrenaline is of little value when α-adrenergic receptors are blocked. Adrenaline should not be used since stimulation of β-adrenergic receptors will further increase blood pressure.


    Manufacturer
    Goldshield Pharmaceuticals Ltd., UK
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