B-Six 300

/ SAM-ON

One tablet a day.

Pyridoxine deficiency (inadequate diet, drug induced B6 dependent convulsion, B6 responsive anemia, alcoholism).

Known hypersensitivity to pyridoxine.

Long-term administration of large doses (2 G or more daily) may cause pyridoxine-induced neurotoxicity, resulting in impairment of senses in distal limbs and ultimately progressive failure of muscular coordination. Following discontinuation, neurological dysfunction gradually improves. Pregnancy and lactation: Potential benefits to the mother must be weighed against the potential hazards to the fetus. Large doses of pyridoxine may result in a pyridoxine dependency syndrome in the neonate. Safety of use in breastfeeding has not been established.

Sensory neuropathic syndromes, unstable gait, numb feet, awkwardness of hands, perioral numbness, decreased sensation to touch, temperature and vibration, paresthesia, somnolence and low serum folic acid levels.

Levodopa, cycloserine, isoniazid. Chloramphenicol, cycloserine, ethionamide, hydralazine, penicillamine, immunosuppressants, estrogens, phenobarbital, phenytoin.