Enzyme Cofactor

2 Drugs classified under this drug class

Enzyme Cofactor. Sapropterin (dihydrochloride) 100 mg.
SOL. TABS: 30, 120 x 100 mg. 5-20 mg/
kg/dly. See lit.
Tmt. HPA in adults, child over 4 yrs with
PKU, shown respons. to such tmt. Tmt.
HPA in adults, child over 4 yrs with BH4
defic., shown respons. to such tmt.
C/I: Hypersens.

Enzyme Cofactor. Sapropterin 100 mg.
Sol. Tabs. 30,120 X 100 mg
PKU (Phenylketonuria)

 

 starting dose in adult and paed. pts. is 10 mg/kg BW once daily. Dose to be adjusted, between 5 and 20 mg/kg/d, to maintain adequate blood phenylalanine levels.
BH4 deficiency
starting dose in adult and paed. pts. is 2 to5 mg/kg BW total daily dose. Doses may be adjusted up to 20 mg/kg/d.
Tmt.of hyperphenylalaninaemia (HPA) in adults and paed. pts. of all ages with phenylketonuria (PKU) who have been shown to be responsive to such tmt.
Tmt.of hyperphenylalaninaemia (HPA) in adults and paed.pts. of all ages with tetrahydrobiopterin (BH4) deficiency who have been shown to be responsive to such tmt.
CI: Hypersens.