All the Drug Class Drugs
α/β Blocker. Carvedilol 6.25 mg, 12.5 mg. TABS: 30. Initial: 3.125 mg 2 x dly. for 2
wks. Incr. at 2 wk. intervals to 6.25 mg 2
x dly. foll. by 12.5 mg 2 x dly, then 25 mg
2 x dly. Max: (less than 85 kg. wt.) 25 mg
2 x dly., (over 85 kg. wt.) 50 mg 2 x dly.
Symt. CHF, adjunct to standard ther., pts.
unable to tolerate ACE inhibit., pts. not
receiv. digitalis, hydralazine, nitrate ther.
C/I: Hypersens., uncontrolled heart fail.,
heart rate lower than 45/min.
(bradycard.), severe hypotens. (systol.
under 85 mmHg).
α/β Blocker. Carvedilol 6.25 mg, 12.5 mg. TABS: 30. Initiat. only under vis.
hosp. physician. Dosage individ. To be
taken with food. Sympt. CHF: Initial:
3.125 mg 2 x dly for 2 wks, may incr. at
intervals of not less than 2 wks to 6.25
mg 2 x dly, follow. by 12.5 mg 2 x dly,
foll. by 25 mg 2 x dly. Max: 25 mg 2 x
dly in pts. < 85 kg, and 50 mg 2 x dly in
pts. > 85 kg. If discont. for more than 2
wks., reinstitut. ther. at 3.125 mg 2 x
dly and titrate as above. Co-exist. ren.
dysfunct: No dose adjust. if systol. BP
above 100 mmHg. Safety/ efficacy
under 18 yrs not estab.
Tmt. sympt. CHF, as adjunct to standard
ther. pts unable to tolerat. ACE inhibs. those
not receiv. digitalis, hydralazine or nitrate
C/I: Hepatic dysfunct., marked fluid
retent., overload req. I.V. inotrop.
support. Obstruct. airways dis.,
hypersens. to carvedilol or constits.,
history of bronchosp./asthma. 2nd, 3rd
degree AV heart block, severe bradycard.
(< 50 bpm), cardiogen. shock, sick sinus
syndr. (incl. sino-artrial block), severe
hypotens., (systol. BP < 85 mmHg), metabol. acidos., pheochromocytoma (unless adeq. controlled by alpha blockade).