All the Active Ingredient Drugs
Oxytocic Agent. Oxytocin 10 IU/ml. Vial 5/10 X 1 ml
Induction or enhancement of labour:
Oxytocin may only be admin. as an intravenous continuous infusion.
10 IU of Oxytocin should be added to 1000 mL of an isotonic sodium chloride solution 0.9%. See prescription info. for dilution and rates.
If regular contractions are still absent after an infus. of 500 mL (5 IU), the attempt at labour induction should be ceased. A fresh attempt can be made on the following day. Frequency, intensity and duration of contractions, as well as the foetal heart rate, must be carefully monitored. As soon as appropriate uterine activity has been achieved, the infus. rate can be reduced. To be discontinued immediately in the event of excessive uterine activity and/or signs of placental malnutrition (foetal distress).
Caesarean section:
Immediately after extraction of the infant, 5 IU can be injected slowly I.V.
Prevention of postpartum uterine haemorrhage:
recomm. dose is 5 IU slowly I.V. after delivery of the placenta. In women given Oxytocin for induction or enhancement of labour, the infusion should be continued at an increased rate during the third stage of labour and for the next few hours thereafter.
Treatment of postpartum uterine haemorrhage:
5-10 IU I.M. or 5 IU slowly I.V., followed in severe cases by IV infus. of a solution containing 5-20 IU of oxytocin in 500 ml of a non-hydrating diluent, run at the rate necessary to control uterine atony.
Due to the antidiuretic effect of Oxytocin which suppresses urine excretion the following measures should be observed when administering this drug at high doses: An isotonic NaCl sol. (not glucose) should be used and the infused vol. of fluid must be kept low. At the same time, oral fluid intake should be restricted and the fluid balance monitored. If an electrolyte imbalance is suspected, serum electrolytes must be monitored.
Incomplete, inevitable or missed abortion:
5 IU I.M. or slowly I.V., if necessary followed by IV infus. at a rate of 20-40 mU/min or higher.
- Induction of labour for med. reasons;
- Stimulation of labour in hypnotic uterine inertia;
- During CS following the delivery of the child;
- Prevent. and tmt. of postpartum uterine atony and hemorrhage.
- In early stages of pregn. as an adjunctive ther. for the management of incomplete, inevitable or missed abortion
C/I: • Hypersens./ Hypertonic uterine contractions, mechan. obstruction to delivery, foetal distress/Any condit. in which, spontaneous labour is inadvisable and/or vaginal delivery is contraindic/ Signif. cephalopelvic disproportion/ Foetal malpresentation/ Placenta praevia and vasa praevia/ Placental abruption/
Cord presentation or prolapse/Overdistension or impaired resistance of the uterus to rupture as in multiple pregn./ Polyhydramnios/Grand multiparity/
In the presence of a uterine scar resulting from major surgery incl. CS./
Should not be used for prolonged periods in pts. with oxytocin-resistant
uterine inertia, sev. pre eclamptic toxaemia or sev. CV dis.
Must not be admin. within 6 hours after vaginal prostaglandins have been given.
Oxytocic Agent. Oxytocin 10 IU/ml. AMPS: 10 x 1 ml. See lit.
Induct. labour for medical reasons,
stimulat. labour in hypoton. uterine inertia, during cesar. sect. foll. delivery,
prevent. tmt. post. partum uterine atony
and hemorrh., early stages pregn. as
adjunct. ther. for manage. incomplete,
inevitable or missed abort.
C/I: Hypersens. See lit.
