All the Active Ingredient Drugs
Benzodiazepine. Lorazepam 4 mg/ml. Amp., sol. 1 ml X5/10 for IM and IV inj.
Premedication
For a max. beneficial effect, dose should be calc. based on BW (usual dose is 2-4 mg) and admin. as follows:
a) I.V. admin.
For an optimal effect, doses of 0.044 mg / kg to a max of 2 mg should be used, 15-20 minutes before the procedure.
This dose (I.V. admin) will be adeq. for sedation of most adult pts and should not normally be exceeded in pats > 50 years.
Higher doses, up to 0.05 mg / kg with a max of 4 mg, can be admin.
The necessary airway equip. must be available immediately prior to the IV admin.
b) I.M. admin:
optimal effect is reached by admin. 0.05mg/kg to a max. 4mg, with min. 2 hours before the procedure. Dose is indiv. adjusted.
In case of local anesthesia and in diagn. procedures requiring ptt involvement, simultaneous use of an analgesic may be appropriate.
The dose should be reduced in case of concom. admin. of central nervous system depressants.
This drug should not be mixed with other drugs in the same syr.
Sympt. tmt. of pathological anxiety and tension in pts who, for some reason, are unable to take oral medication.
Recommended initial dose is 2-4 mg I.V. or 0.05 mg / kg I.M. (IV admin. is preferred). If necessary, dose may be repeated after 2 hours. As soon as the acute symptomat. is controlled, the pttt must receive appropriate tmt for the underlying condition. The use of lorazepam tablets may be considered if further tmt. with benzodiazepines is required.
Status epilepticus
Adults: 4 mg IV.
Elderly: The elderly may respond to lower doses; thus, half the normal adult dose may be sufficient.
Pediatric population (age >1 month): 0.1 mg/kg BW intravenously. Maximum 4 mg/dose
In adults and adolescents > 12 years::
As premedication, before surgical procedures or prior to diagn. procedures.
For symptom. treatment of pathological anxiety and tension in pts who, for some reason, are unable to take oral medic..
in adults, adolescents, children and infants from 1 month of age: for the control of status epilepticus.
C/I: Hypersens incl to benzodiazepines./ not to be admin. intra-arterially. As with other injectable benzodiazepines, an intra-arterial injection may cause arterial spasm that causes gangrene and may require amputation. Contraindic. in pts with:
sleep apnoea syndrome;/ sev. respir. insuff;/ myasthenia gravis;/
sev. hepatic insuff.
In childr < 12 years, except in the control of status epilepticus
Benzodiazepine. Lorazepam 1 mg. TABS: 20, 50.
Adults: 1-4 mg daily in divided doses;
Elderly and debilitated patients: may
respond to lower doses and half the
normal adult dose or less may be
sufficient. This initial dose should be
adjusted as needed and tolerated.
Children (under the age of 13 years):
Lorazepam is not intended for the
treatment of children under the age of
13 years; Patients with Renal or Hepatic
Impairment: Lower doses may be
sufficient in patients with impaired
renal function or mild to moderate
hepatic insufficiency. Use in patients
with severe hepatic insufficiency is
contraindicated. See Lit.
Anxiety and tension.
C/I: Hypersensitivity to Lorazepam, other
benzodiazepines or to any other of the
excipients. Acute pulmonary
insufficiency: respiratory depression;
sleep apnoea (risk of further respiratory
depression); Severe respiratory
insufficiency; Obsessional states
(inadequate evidence of safety and
efficacy); Planning a pregnancy;
Pregnancy (unless there are compelling
reasons); Myasthenia gravis; Severe
hepatic insufficiency (may precipitate
encephalopathy); Acute narrow-angle glaucoma. Benzodiazepines should not be used alone in anxiety with depression
(may precipitate suicide). See Lit.
