Who are we?
Dexcel Pharma is Israel’s largest private pharmaceutical company. Founded in 1968, we develop, manufacture and market value-added branded and generic pharmaceuticals. With a diverse product portfolio that spans more than 85 branded and generic products in over 175 dosage forms, our products are sold in the US, the UK and Germany, via subsidiaries and through a trusted network of partners in more than 30 countries worldwide.
Drugs Disributed by Dexcel Ltd.
ACE Inhibitor. Captopril 12.5, 25, 50 mg. TABS: 90 x 12.5mg, 25mg, 50mg.
Max. dly. dose: 150 mg. Hypertens: Initial: 25-50 mg 2 x dly in div. doses. Incr.
intervals at least 2 wks: 100-150 mg dly in div. doses to reach target BP.
Heart fail.: Init.: 12.5 mg BID or TID.
Titrat. to maint. dose (75-150 mg dly) at intervals of at least 2 wks. depen. on pt. response.
Type 1 diabet. nephropathy: 75-100 mg dly in div doses.
MI, ren. impair., elderly: See lit.
Hypertens., C.H.F., insulin depend. diabet. nephropathy in hypertens./nonhypertens. pts. when serum creatinine level < 2.5 mg/dl. Improve survival follow. MI in clinic. stable pts. with left ventric. dysfunct. manifest. as eject. fract. < or equals 40% and to reduce incidence of overt heart fail. and subseq. hospitalizat. for C.H.F. in these pts.
C/I: Hypersens. Hypersens. to other ACE inhib.
Hist. of angioedema assoc. with previous ACE-inhib. ther., hered. idiopath. angioedema. 2nd, 3rd trim. of preg.
Concom. use with aliskiren contain. product in pts. with diab. mell. or renal impair. (GFR <60ml/min/1.73 m2). See lit.
NSAID. Ibuprofen 200 mg. CAPS: 16, 40. Adults, elderly and
children over 12 yrs: 200-400 mg, up to
3 times a day. Leave at least 4 hrs
between doses. Do not exceed 1200
mg in 24 hrs. With/immed. aft. meal.
Children: under med. supervis.
For the tmt. of pain assoc. with migraine.
Relief of mild – mod. pain such as
headache, toothache, primary
dysmenorrhea, backache, muscular pain,
anti-inflamm., relieves pain in rheum.
arthritis and Osteoarthr. For the reduct.
of fever.
C/I: Hypersens. to ibuprofen or other
ingr. of the product, prev. hypersens.
reactions (e.g. asthma, rhinitis,
angioedema or urticaria) in response to
aspirin or other NSAIDs, history of, or
exist. GI ulcer./perfor. or bleed. incl. that
assoc. with NSAIDs, sev. hepatic fail., sev.
renal fail., sev. heart fail., concom. use
with NSAIDs, incl. COX2 inh. – incr. risk of
ADR , last trim. of pregn.; and see lit.
NSAID. Ibuprofen 400 mg. CAPS: 40. Adults, elderly and children
over 12 yrs: 200-400 mg, up to 3 times
a day. Leave at least 4 hrs between
doses. Do not exceed 1200 mg in 24
hrs. With/immed. aft. meal. Children:
under med. supervis.
For the tmt. of pain assoc. with migraine.
Relief of mild – mod. pain such as
headache, toothache, primary
dysmenorrhea, backache, muscular pain,
anti-inflamm., relieves pain in rheum.
arthritis and Osteoarthr.
C/I: Hypersens. to ibuprofen or other
ingr. of the product, prev. hypersens.
reactions (e.g. asthma, rhinitis,
angioedema or urticaria) in response to
aspirin or other NSAIDs, history of, or exist. GI ulcer./perfor. or bleed. incl. that
assoc. with NSAIDs, sev. hepatic fail., sev.
renal fail., sev. heart fail., concom. use
with NSAIDs, incl. COX2 inh. – incr. risk of
ADR , last trim. of pregn.; and see lit.
NSAID. Ibuprofen 200 mg. LIQ. FILLED CAPS: 16, 30 x 200 mg. Adults, elderly and children over 12 yrs: 200-400 mg, up to 3 times a day. Leave at least 4 hrs between doses. Do not exceed 1200 mg in 24 hrs. With/immed. aft. meal. Children: under med. supervis.
For the tmt. of pain assoc. with migraine. Relief of mild – mod. pain such as headache, toothache, primary dysmenorrhea, backache, muscular pain, anti-inflamm., relieves pain in rheum. dis., reduct. of fever.
C/I: Hypersens. to ibuprofen or other ingr. of the product, prev. hypersens. reactions (e.g. asthma, rhinitis, angioedema or urticaria) in response to aspirin or other NSAIDs, history of, or exist. GI ulcer./
perfor. or bleed. incl. that assoc. with NSAIDs, sev. hepatic fail., sev. renal fail., sev. heart fail., concom. use with NSAIDs, incl. COX2 inh. – incr. risk of ADR , last trim. of pregn.; and see lit.
NSAID. Ibuprofen 400 mg. LIQ. FILLED CAPS: 20 x 400 mg. Adults, elderly and children over 12 yrs: 200-400 mg, up to 3 times a day. Leave at least 4 hrs between doses. Do not exceed 1200 mg in 24 hrs. With/immed. aft. meal. Children: under med. supervis.
For the tmt. of pain assoc. with migraine.
Relief of mild – mod. pain
such as headache, toothache, primary
dysmenorrhea, backache, muscular pain,
anti-inflamm., relieves pain in rheum.
dis., reduct. of fever.
C/I: Hypersens. to ibuprofen or other
ingr. of the product, prev. hypersens.
reactions (e.g. asthma, rhinitis,
angioedema or urticaria) in response to
aspirin or other NSAIDs, history of, or
exist. GI ulcer./perfor. or bleed. incl. that
assoc. with NSAIDs, sev. hepatic fail., sev.
renal fail., sev. heart fail., concom. use
with NSAIDs, incl. COX2 inh. – incr. risk of
ADR , last trim. of pregn.; and see lit.
Xanthine Oxidase Inhibitor. Allopurinol 100 mg, 300 mg. TABS: 50 x 100mg, 20, 30 x 300mg.
Init.: 100 mg dly. Mild: 100-200 mg dly.
Moderat. sev.: 300-600 mg dly.
Sev.: 700-800 mg dly. If dosage on mg/
kg bdywght. basis is required, 2-10 mg/
kg bdywght./d. should be used.
Once dly. after a meal. Should the dly.
dosage exceed 300 mg and GI intoler.
be manifested, a divided doses regim.
may be appropr. The dosage should be
adjust. by monitor. serum urate
concentr. and urin. urate/uric acid
levels at appropr. interval. See lit.
Ped. popul.: child. <15 yrs. : 10 to 20
mg/kg bdywght./d. up to a max. of 400
mg dly. See lit.
Ren. impair. : In sev. renal impair. a
single doses of 100 mg at long. interv.
than one day is advised. If dialysis is
required 2 -3 times/wk. of 300-400 mg
immed. after each dialysis with none in
the interim.
Hep. impair.: Reduced doses should be
used in pts. with hep. impair. Period.
hep. funct. monitor. during the early
stages of ther. See lit.
Tmt. of high urate turnover condit.,
Dosage of Allopurinol should be at the
lower end of the recomm. dosage
schedule. See lit.
Manag. of pts. with signs & sympt. of
prim. or second. gout (acute attacks,
tophi, joint destruct., uric acid lithiasis
and/or nephrop.).
Manag.. of pts. with leukemia,
lymphoma, & malignan. who are receiv.
cancer ther. which causes elevat. of
serum & urin. uric acid levels.
Manag. of pts. with recur. calcium
oxalate calculi whose dly. uric acid excret. exceeds 800 mg/d. in male pts. and 750
mg/d in female pts.
Ther. in such pts. should be careful.
assessed init.and reassessed period.to
determ. in each case that tmt. is benefic.
and that the benefits outweigh the risks.
C/I: Hypersens.
